| 18‑Jul‑2011 | Atlanta | Hard | F | 35 | 9 | (1)Mardy Fish [USA] d. (3)Isner | 3-6 7-6(6) 6-2 | | 0.58 | 16.0% | 6.4% | 69.1% | 70.8% | 44.8% | 3/6 | 2:16 |
| 14‑Feb‑2011 | Memphis | Hard | R32 | 24 | 298 | (WC)Juan Martin Del Potro [ARG] d. (6)Isner | 6-4 6-3 | | 0.64 | 19.4% | 6.5% | 53.2% | 69.7% | 44.8% | 1/4 | 1:14 |
| 6‑Mar‑2014 | Indian Wells Masters | Hard | SF | 13 | 2 | (2)Novak Djokovic [SRB] d. (12)Isner | 7-5 6-7(2) 6-1 | (ch) | 0.76 | 7.0% | 1.8% | 68.4% | 62.8% | 44.4% | 7/12 | 2:24 |
| 7‑Jan‑2013 | Sydney | Hard | R16 | 13 | 68 | (Q)Ryan Harrison [USA] d. (1)Isner | 6-4 6-4 | | 0.75 | 17.2% | 1.7% | 69.0% | 75.0% | 44.4% | 3/5 | 1:15 |
| 18‑Jul‑2011 | Atlanta | Hard | QF | 35 | 85 | (3)Isner d. Yen Hsun Lu [TPE] | 6-1 6-2 | | 2.51 | 19.0% | 2.4% | 78.6% | 87.9% | 44.4% | 1/1 | 0:56 |
| 1‑Nov‑2010 | Basel | Hard | R32 | 19 | 35 | (8)Isner d. Michael Llodra [FRA] | 4-6 7-5 6-3 | | 1.43 | 25.6% | 1.3% | 76.9% | 83.3% | 44.4% | 1/3 | 1:45 |
| 11‑Mar‑2010 | Indian Wells Masters | Hard | R16 | 20 | 3 | (3)Rafael Nadal [ESP] d. (15)Isner | 7-5 3-6 6-3 | | 0.57 | 21.0% | 1.0% | 65.7% | 73.9% | 44.4% | 7/9 | 2:11 |
| 14‑Aug‑2011 | Cincinnati Masters | Hard | R64 | 27 | 29 | (Q)Radek Stepanek [CZE] d. Isner | 7-5 5-7 7-6(4) | | 1.08 | 19.6% | 2.8% | 76.6% | 80.5% | 44.0% | 3/4 | 2:46 |
| 16‑May‑2010 | Dusseldorf | Clay | RR | 19 | 33 | Lleyton Hewitt [AUS] d. Isner | 6-2 6-4 | | 0.53 | 10.2% | 0.0% | 72.9% | 51.2% | 43.8% | 3/7 | 1:06 |
| 16‑Jan‑2012 | Australian Open | Hard | R32 | 17 | 19 | (18)Feliciano Lopez [ESP] d. (16)Isner | 6-3 6-7(3) 6-4 6-7(0) 6-1 | | 0.83 | 19.7% | 2.0% | 73.5% | 72.2% | 43.6% | 5/11 | 3:26 |
| 29‑Sep‑2014 | Beijing | Hard | R16 | 15 | 21 | (8)Isner d. Tommy Robredo [ESP] | 3-6 7-5 7-6(4) | | 0.92 | 14.7% | 4.6% | 66.1% | 73.6% | 43.2% | 1/4 | 2:12 |
| 28‑Jul‑2014 | Washington | Hard | R32 | 12 | 68 | Steve Johnson [USA] d. (5)Isner | 6-7(5) 6-3 7-6(6) | | 0.74 | 28.2% | 2.9% | 64.1% | 89.4% | 43.2% | 1/2 | 2:07 |
| 29‑Sep‑2014 | Beijing | Hard | QF | 15 | 6 | (3)Tomas Berdych [CZE] d. (8)Isner | 6-1 6-4 | | 0.59 | 16.4% | 1.8% | 61.8% | 61.8% | 42.9% | 5/8 | 1:14 |
| 4‑Aug‑2014 | Canada Masters | Hard | R64 | 14 | 62 | Ivan Dodig [CRO] d. (10)Isner | 6-4 6-7(4) 6-3 | | 0.68 | 14.1% | 6.5% | 62.0% | 84.2% | 42.9% | 7/9 | 1:52 |
| 6‑Mar‑2014 | Indian Wells Masters | Hard | QF | 13 | 22 | (12)Isner d. (20)Ernests Gulbis [LAT] | 7-6(4) 7-6(3) | | 1.20 | 16.3% | 3.8% | 73.8% | 81.4% | 42.9% | 3/4 | 1:49 |
| 20‑Mar‑2013 | Miami Masters | Hard | R64 | 23 | 54 | (20)Isner d. Ivan Dodig [CRO] | 4-6 7-5 7-6(5) | | 1.15 | 25.3% | 0.0% | 70.5% | 82.1% | 42.9% | 3/7 | 2:09 |
| 27‑Feb‑2012 | Delray Beach | Hard | SF | 11 | 36 | (7)Kevin Anderson [RSA] d. (1)Isner | 7-5 7-6(4) | | 0.77 | 23.5% | 4.4% | 69.1% | 87.2% | 42.9% | 2/3 | 1:36 |
| 9‑Jan‑2012 | Sydney | Hard | R16 | 17 | 126 | (Q)Bobby Reynolds [USA] d. (2)Isner | 3-6 6-4 6-3 | | 0.80 | 22.0% | 3.3% | 61.5% | 73.2% | 42.9% | 4/7 | 1:52 |
| 21‑Aug‑2011 | Winston-Salem | Hard | QF | 28 | 60 | (4)Isner d. (8)Marcos Baghdatis [CYP] | 1-6 6-3 6-4 | | 0.86 | 15.4% | 5.1% | 64.1% | 74.0% | 42.9% | 0/3 | 1:51 |
| 24‑Mar‑2010 | Miami Masters | Hard | R32 | 21 | 14 | (12)Juan Carlos Ferrero [ESP] d. (17)Isner | 6-2 3-6 6-3 | | 0.78 | 19.2% | 2.6% | 64.1% | 76.0% | 42.9% | 4/7 | 1:41 |
| 31‑Oct‑2011 | Valencia | Hard | R32 | 23 | 133 | (Q)Vasek Pospisil [CAN] d. Isner | 6-3 3-6 7-6(9) | | 0.97 | 20.2% | 6.4% | 74.5% | 85.7% | 41.7% | 2/3 | 2:13 |
| 21‑Aug‑2011 | Winston-Salem | Hard | F | 28 | 113 | (4)Isner d. (Q)Julien Benneteau [FRA] | 4-6 6-3 6-4 | | 1.00 | 22.4% | 5.9% | 71.8% | 83.6% | 41.7% | 2/3 | 2:01 |
| 6‑Aug‑2012 | Canada Masters | Hard | QF | 11 | 24 | (8)Isner d. (16)Milos Raonic [CAN] | 7-6(9) 6-4 | | 1.39 | 11.6% | 7.2% | 68.1% | 91.5% | 40.9% | 0/1 | 1:31 |
| 13‑Jan‑2014 | Australian Open | Hard | R128 | 13 | 106 | (LL)Martin Klizan [SVK] d. (13)Isner | 6-2 7-6(6) RET | | 0.46 | 14.9% | 0.0% | 77.6% | 69.2% | 40.0% | 3/5 | 1:22 |
| 21‑Feb‑2011 | Delray Beach | Hard | R32 | 32 | 76 | Teymuraz Gabashvili [RUS] d. (4)Isner | 6-4 5-7 7-6(13) | | 0.78 | 19.1% | 3.6% | 77.3% | 80.0% | 40.0% | 3/5 | 2:31 |
| 11‑Jan‑2010 | Auckland | Hard | QF | 33 | 16 | Isner d. (1)Tommy Robredo [ESP] | 7-6(5) 3-6 6-4 | | 1.06 | 19.6% | 3.9% | 72.5% | 75.7% | 39.3% | 9/12 | 2:12 |
| 30‑Aug‑2010 | US Open | Hard | R32 | 20 | 14 | (12)Mikhail Youzhny [RUS] d. (18)Isner | 6-4 6-7(7) 7-6(5) 6-4 | | 0.92 | 22.3% | 1.4% | 68.2% | 77.2% | 38.3% | 8/12 | 3:18 |
| 28‑Oct‑2013 | Paris Masters | Hard | R16 | 16 | 2 | (2)Novak Djokovic [SRB] d. (13)Isner | 6-7(5) 6-1 6-2 | (ch) | 0.44 | 10.8% | 1.8% | 78.4% | 62.1% | 37.5% | 12/16 | 1:50 |
| 27‑Oct‑2014 | Paris Masters | Hard | R32 | 16 | 21 | Gael Monfils [FRA] d. (13)Isner | 6-4 7-6(4) | | 0.67 | 10.6% | 1.2% | 74.1% | 74.6% | 36.4% | 8/9 | 1:33 |
| 29‑Jul‑2013 | Washington | Hard | F | 20 | 7 | (1)Juan Martin Del Potro [ARG] d. (8)Isner | 3-6 6-1 6-2 | (ch) | 0.66 | 9.2% | 6.2% | 66.2% | 69.8% | 36.4% | 2/6 | 1:29 |
| 14‑Apr‑2013 | Monte Carlo Masters | Clay | R64 | 23 | 56 | Ernests Gulbis [LAT] d. (WC)Isner | 4-6 6-2 6-3 | | 0.59 | 6.5% | 0.0% | 64.5% | 63.3% | 36.4% | 9/13 | 1:49 |
| 16‑May‑2010 | Dusseldorf | Clay | RR | 19 | 17 | Tomas Berdych [CZE] d. Isner | 1-6 6-1 7-6(4) | | 0.90 | 9.3% | 2.1% | 68.0% | 69.7% | 35.5% | 7/10 | 2:16 |
| 20‑Mar‑2013 | Miami Masters | Hard | R32 | 23 | 11 | (9)Marin Cilic [CRO] d. (20)Isner | 6-3 7-6(3) | | 0.60 | 30.8% | 1.5% | 64.6% | 76.2% | 34.8% | 4/6 | 1:18 |
| 4‑Oct‑2010 | Beijing | Hard | SF | 22 | 2 | (1)Novak Djokovic [SRB] d. (WC)Isner | 7-6(1) 6-2 | | 0.51 | 8.9% | 3.8% | 64.6% | 68.6% | 32.1% | 9/12 | 1:27 |
| 10‑Mar‑2011 | Indian Wells Masters | Hard | R32 | 33 | 8 | (8)Andy Roddick [USA] d. (30)Isner | 7-5 6-2 | | 0.40 | 27.8% | 3.7% | 70.4% | 76.3% | 31.3% | 0/3 | 1:08 |
| 18‑Feb‑2013 | Memphis | Hard | R32 | 16 | 63 | Denis Istomin [UZB] d. (3)Isner | 6-4 6-3 | | 0.35 | 13.8% | 10.3% | 65.5% | 76.3% | 30.0% | 4/7 | 1:00 |
| 24‑May‑2010 | Roland Garros | Clay | R32 | 19 | 17 | (15)Tomas Berdych [CZE] d. (17)Isner | 6-2 6-2 6-1 | | 0.35 | 9.9% | 1.1% | 73.6% | 55.2% | 29.2% | 5/12 | 1:33 |
| 18‑Jan‑2010 | Australian Open | Hard | R16 | 28 | 4 | (5)Andy Murray [GBR] d. (33)Isner | 7-6(4) 6-3 6-2 | (ch) | 0.52 | 15.7% | 2.2% | 68.5% | 70.5% | 28.6% | 3/5 | 2:12 |
| 8‑May‑2011 | Rome Masters | Clay | R64 | 35 | 42 | Juan Ignacio Chela [ARG] d. Isner | 6-4 6-1 | | 0.51 | 3.6% | 1.8% | 67.9% | 63.2% | 27.8% | 1/5 | 1:12 |
| 30‑Sep‑2013 | Beijing | Hard | QF | 16 | 5 | (4)Tomas Berdych [CZE] d. (8)Isner | 7-5 6-2 | | 0.85 | 13.4% | 3.0% | 53.7% | 75.0% | 25.8% | 3/8 | 1:30 |
