| 28‑Oct‑2013 | Paris Masters | Hard | R16 | 16 | 2 | (2)Novak Djokovic [SRB] d. (13)Isner | 6-7(5) 6-1 6-2 | (ch) | 0.44 | 10.8% | 1.8% | 78.4% | 62.1% | 37.5% | 12/16 | 1:50 |
| 30‑Sep‑2013 | Beijing | Hard | QF | 16 | 5 | (4)Tomas Berdych [CZE] d. (8)Isner | 7-5 6-2 | | 0.85 | 13.4% | 3.0% | 53.7% | 75.0% | 25.8% | 3/8 | 1:30 |
| 11‑Aug‑2013 | Cincinnati Masters | Hard | F | 22 | 3 | (4)Rafael Nadal [ESP] d. Isner | 7-6(8) 7-6(3) | (ch) | 0.72 | 13.6% | 1.2% | 76.5% | 74.2% | 68.4% | 0/0 | 1:55 |
| 11‑Aug‑2013 | Cincinnati Masters | Hard | SF | 22 | 7 | Isner d. (7)Juan Martin Del Potro [ARG] | 6-7(5) 7-6(9) 6-3 | (ch) | 1.04 | 18.1% | 4.7% | 66.1% | 77.4% | 48.8% | 6/7 | 2:48 |
| 11‑Aug‑2013 | Cincinnati Masters | Hard | QF | 22 | 1 | Isner d. (1)Novak Djokovic [SRB] | 7-6(5) 3-6 7-5 | | 1.31 | 9.7% | 0.0% | 74.2% | 79.7% | 62.5% | 3/4 | 2:24 |
| 11‑Aug‑2013 | Cincinnati Masters | Hard | R16 | 22 | 10 | Isner d. (12)Milos Raonic [CAN] | 7-6(5) 6-4 | | 1.37 | 19.4% | 3.0% | 58.2% | 82.1% | 64.3% | 0/1 | 1:37 |
| 29‑Jul‑2013 | Washington | Hard | F | 20 | 7 | (1)Juan Martin Del Potro [ARG] d. (8)Isner | 3-6 6-1 6-2 | (ch) | 0.66 | 9.2% | 6.2% | 66.2% | 69.8% | 36.4% | 2/6 | 1:29 |
| 5‑Apr‑2013 | Davis Cup WG QF: USA vs SRB | Hard | RR | 23 | 1 | Novak Djokovic [SRB] d. Isner | 7-6(5) 6-2 7-5 | | | | | | | | | |
| 14‑Sep‑2012 | Davis Cup WG SF: ESP vs USA | Clay | RR | 10 | 5 | David Ferrer [ESP] d. Isner | 6-7(3) 6-3 6-4 6-2 | | | | | | | | | |
| 19‑Aug‑2012 | Winston-Salem | Hard | F | 10 | 7 | (3)Isner d. (2)Tomas Berdych [CZE] | 3-6 6-4 7-6(9) | | 1.02 | 23.9% | 1.1% | 69.6% | 76.6% | 57.1% | 3/5 | 2:27 |
| 19‑Aug‑2012 | Winston-Salem | Hard | SF | 10 | 6 | (3)Isner d. (1)Jo Wilfried Tsonga [FRA] | 6-4 3-6 7-6(3) | | 1.10 | 25.3% | 2.1% | 64.2% | 82.0% | 47.1% | 2/3 | 2:13 |
| 25‑Jul‑2012 | London Olympics | Grass | QF | 11 | 1 | (1)Roger Federer [SUI] d. (10)Isner | 6-4 7-6(5) | (ch) | 0.98 | 11.8% | 1.5% | 72.1% | 75.5% | 63.2% | 3/4 | 1:25 |
| 25‑Jul‑2012 | London Olympics | Grass | R16 | 11 | 8 | (10)Isner d. (7)Janko Tipsarevic [SRB] | 7-5 7-6(14) | | 1.52 | 30.6% | 0.0% | 83.3% | 91.7% | 50.0% | 0/0 | 1:30 |
| 6‑Apr‑2012 | Davis Cup WG QF: FRA vs USA | Clay | RR | 11 | 6 | Isner d. Jo Wilfried Tsonga [FRA] | 6-3 7-6(4) 5-7 6-3 | | | | | | | | | |
| 8‑Mar‑2012 | Indian Wells Masters | Hard | F | 11 | 3 | (3)Roger Federer [SUI] d. (11)Isner | 7-6(7) 6-3 | | 0.46 | 5.6% | 1.4% | 73.2% | 71.2% | 47.4% | 1/3 | 1:22 |
| 8‑Mar‑2012 | Indian Wells Masters | Hard | SF | 11 | 1 | (11)Isner d. (1)Novak Djokovic [SRB] | 7-6(7) 3-6 7-6(5) | (ch) | 0.85 | 17.9% | 0.0% | 74.1% | 72.3% | 51.7% | 4/6 | 2:46 |
| 10‑Feb‑2012 | Davis Cup WG R1: SUI vs USA | Clay | RR | 17 | 3 | Isner d. Roger Federer [SUI] | 4-6 6-3 7-6(4) 6-2 | | | | | | | | | |
