| 29‑Oct‑2012 | Paris Masters | Hard | R16 | 17 | 5 | (4)David Ferrer [ESP] d. (16)Wawrinka | 6-2 4-6 6-2 | | 0.72 | 4.6% | 3.4% | 59.8% | 61.5% | 42.9% | 9/14 | 2:03 |
| 7‑Oct‑2012 | Shanghai Masters | Hard | R16 | 17 | 1 | (1)Roger Federer [SUI] d. (13)Wawrinka | 4-6 7-6(4) 6-0 | (ch) | 0.76 | 7.6% | 1.1% | 48.9% | 64.4% | 46.8% | 5/9 | 1:56 |
| 1‑Oct‑2012 | Tokyo | Hard | QF | 16 | 3 | (1)Andy Murray [GBR] d. (7)Wawrinka | 6-2 3-6 6-2 | | 0.81 | 5.6% | 1.1% | 48.3% | 69.8% | 50.0% | 7/11 | 2:01 |
| 27‑Aug‑2012 | US Open | Hard | R16 | 19 | 2 | (2)Novak Djokovic [SRB] d. (18)Wawrinka | 6-4 6-1 3-1 RET | | 0.70 | 8.8% | 5.3% | 40.4% | 65.2% | 35.3% | 1/5 | 1:33 |
| 12‑Aug‑2012 | Cincinnati Masters | Hard | SF | 26 | 1 | (1)Roger Federer [SUI] d. Wawrinka | 7-6(4) 6-3 | (ch) | 0.65 | 7.2% | 2.4% | 55.4% | 69.6% | 51.4% | 8/10 | 1:35 |
| 12‑Aug‑2012 | Cincinnati Masters | Hard | R32 | 26 | 5 | Wawrinka d. (4)David Ferrer [ESP] | 6-4 6-1 | | 2.51 | 21.4% | 2.4% | 64.3% | 92.6% | 60.0% | 2/2 | 1:13 |
| 25‑Jul‑2012 | London Olympics | Grass | R64 | 26 | 4 | (3)Andy Murray [GBR] d. Wawrinka | 6-3 6-3 | (ch) | 0.64 | 6.5% | 5.2% | 45.5% | 68.6% | 47.6% | 10/13 | 1:29 |
| 27‑May‑2012 | Roland Garros | Clay | R16 | 21 | 5 | (5)Jo Wilfried Tsonga [FRA] d. (18)Wawrinka | 6-4 7-6(6) 3-6 3-6 6-4 | (ch) | 0.98 | 2.3% | 1.1% | 63.2% | 70.9% | 43.8% | 8/13 | 4:06 |
| 13‑May‑2012 | Rome Masters | Clay | R32 | 20 | 8 | Wawrinka d. (8)Janko Tipsarevic [SRB] | 6-3 6-1 | | 1.34 | 5.2% | 1.7% | 60.3% | 57.1% | 60.9% | 3/5 | 1:12 |
| 6‑May‑2012 | Madrid Masters | Clay | R16 | 21 | 1 | (1)Novak Djokovic [SRB] d. Wawrinka | 7-6(5) 6-4 | | 0.57 | 8.5% | 4.9% | 52.4% | 74.4% | 43.6% | 8/10 | 1:45 |
| 15‑Apr‑2012 | Monte Carlo Masters | Clay | QF | 26 | 2 | (2)Rafael Nadal [ESP] d. Wawrinka | 7-5 6-4 | | 0.66 | 7.1% | 4.3% | 52.9% | 70.3% | 48.5% | 4/7 | 1:47 |
| 10‑Feb‑2012 | Davis Cup WG R1: SUI vs USA | Clay | RR | 28 | 8 | Mardy Fish [USA] d. Wawrinka | 6-2 4-6 4-6 6-1 9-7 | | | | | | | | | |
| 16‑Jan‑2012 | Australian Open | Hard | R32 | 22 | 10 | (10)Nicolas Almagro [ESP] d. (21)Wawrinka | 7-6(2) 6-2 6-4 | | 0.68 | 3.4% | 1.7% | 61.0% | 56.9% | 45.7% | 11/17 | 2:27 |
