| 19‑Mar‑2025 | Miami | Hard | R64 | 23 | 892 | (22)Khachanov d. (PR)Nick Kyrgios [AUS] | 7-6(3) 6-0 | | 2.18 | 15.1% | 1.9% | 75.5% | 85.0% | 61.5% | 2/2 | 1:16 |
| 5‑Mar‑2025 | Indian Wells Masters | Hard | R64 | 23 | 57 | (22)Khachanov d. Jakub Mensik [CZE] | 3-6 6-0 6-3 | | 1.19 | 2.6% | 2.6% | 60.5% | 71.7% | 50.0% | 5/7 | 1:59 |
| 24‑Feb‑2025 | Dubai | Hard | R32 | 24 | 178 | Khachanov d. (WC)Daniel Evans [GBR] | 6-1 6-3 | | 1.89 | 0.0% | 2.0% | 55.1% | 74.1% | 68.2% | 3/4 | 1:20 |
| 28‑Oct‑2024 | Paris Masters | Hard | R32 | 21 | 31 | Khachanov d. (WC)Giovanni Mpetshi Perricard [FRA] | 6-7(12) 6-1 6-4 | | 2.47 | 7.4% | 0.0% | 69.1% | 92.9% | 76.0% | 0/0 | 1:54 |
| 21‑Oct‑2024 | Vienna | Hard | QF | 24 | 41 | Khachanov d. Matteo Berrettini [ITA] | 6-1 6-4 | | 1.65 | 9.6% | 0.0% | 63.5% | 78.8% | 68.4% | 2/2 | 1:18 |
| 12‑Aug‑2024 | Cincinnati Masters | Hard | R64 | 22 | 28 | Khachanov d. Francisco Cerundolo [ARG] | 6-0 6-3 | (ch) | 1.73 | 18.8% | 6.3% | 64.6% | 77.4% | 52.9% | 2/2 | 1:04 |
| 27‑May‑2024 | Roland Garros | Clay | R128 | 18 | 95 | (18)Khachanov d. Sumit Nagal [IND] | 6-2 6-0 7-6(5) | | 1.40 | 8.1% | 2.0% | 63.6% | 76.2% | 50.0% | 8/9 | |
