| 13‑Jan‑2025 | Australian Open | Hard | QF | 1 | 8 | (1)Sinner d. (8)Alex De Minaur [AUS] | 6-3 6-2 6-1 | (ch) | 2.80 | 3.4% | 0.0% | 64.4% | 84.2% | 81.0% | 1/1 | 1:48 |
| 13‑Jan‑2025 | Australian Open | Hard | R64 | 1 | 173 | (1)Sinner d. (WC)Tristan Schoolkate [AUS] | 4-6 6-4 6-1 6-3 | (ch) | 1.40 | 14.0% | 5.0% | 62.0% | 77.4% | 55.3% | 0/1 | 2:46 |
| 13‑Jan‑2025 | Australian Open | Hard | R128 | 1 | 36 | (1)Sinner d. Nicolas Jarry [CHI] | 7-6(2) 7-6(5) 6-1 | (ch) | 1.48 | 6.9% | 1.0% | 57.4% | 82.8% | 69.8% | 2/2 | 2:40 |
| 21‑Nov‑2024 | Davis Cup Finals QF: ITA vs ARG | Hard | RR | 1 | 27 | Sinner d. Sebastian Baez [ARG] | 6-2 6-1 | | 1.74 | 12.1% | 3.4% | 53.4% | 71.0% | 63.0% | 4/4 | 1:12 |
| 11‑Nov‑2024 | Tour Finals | Hard | SF | 1 | 7 | (1)Sinner d. (6)Casper Ruud [NOR] | 6-1 6-2 | (ch) | 2.06 | 19.6% | 0.0% | 58.7% | 81.5% | 63.2% | 2/2 | 1:09 |
| 2‑Oct‑2024 | Shanghai Masters | Hard | QF | 1 | 5 | (1)Sinner d. (5)Daniil Medvedev [RUS] | 6-1 6-4 | (ch) | 1.94 | 18.0% | 0.0% | 66.0% | 84.8% | 58.8% | 1/1 | 1:24 |
| 2‑Oct‑2024 | Shanghai Masters | Hard | R64 | 1 | 93 | (1)Sinner d. Taro Daniel [JPN] | 6-1 6-4 | | 1.91 | 24.5% | 2.0% | 77.6% | 84.2% | 45.5% | 0/0 | 1:17 |
| 26‑Sep‑2024 | Beijing | Hard | R32 | 1 | 28 | (1)Sinner d. Nicolas Jarry [CHI] | 4-6 6-3 6-1 | (ch) | 1.86 | 1.5% | 1.5% | 68.2% | 82.2% | 66.7% | 4/5 | 1:55 |
| 26‑Aug‑2024 | US Open | Hard | QF | 1 | 5 | (1)Sinner d. (5)Daniil Medvedev [RUS] | 6-2 1-6 6-1 6-4 | (ch) | 1.42 | 4.1% | 1.0% | 52.6% | 76.5% | 60.9% | 6/8 | 2:39 |
| 26‑Aug‑2024 | US Open | Hard | R16 | 1 | 14 | (1)Sinner d. (14)Tommy Paul [USA] | 7-6(3) 7-6(5) 6-1 | (ch) | 1.40 | 10.2% | 1.0% | 49.0% | 81.3% | 56.0% | 2/4 | 2:42 |
| 26‑Aug‑2024 | US Open | Hard | R32 | 1 | 87 | (1)Sinner d. Christopher Oconnell [AUS] | 6-1 6-4 6-2 | (ch) | 2.10 | 21.7% | 2.9% | 65.2% | 82.2% | 66.7% | 0/0 | 1:53 |
| 26‑Aug‑2024 | US Open | Hard | R128 | 1 | 140 | (1)Sinner d. Mackenzie Mcdonald [USA] | 2-6 6-2 6-1 6-2 | (ch) | 1.38 | 11.7% | 5.3% | 55.3% | 75.0% | 50.0% | 7/11 | 2:24 |
| 5‑Aug‑2024 | Canada Masters | Hard | QF | 1 | 8 | (5)Andrey Rublev [RUS] d. (1)Sinner | 6-3 1-6 6-2 | (ch) | 0.96 | 13.7% | 5.5% | 58.9% | 74.4% | 43.3% | 4/7 | 1:47 |
| 1‑Jul‑2024 | Wimbledon | Grass | R32 | 1 | 52 | (1)Sinner d. Miomir Kecmanovic [SRB] | 6-1 6-4 6-2 | (ch) | 1.94 | 15.9% | 2.9% | 60.9% | 85.7% | 66.7% | 1/1 | 1:36 |
| 27‑May‑2024 | Roland Garros | Clay | R16 | 2 | 79 | (2)Sinner d. Corentin Moutet [FRA] | 2-6 6-3 6-2 6-1 | (ch) | 1.39 | 5.3% | 5.3% | 65.3% | 72.6% | 42.4% | 2/6 | |
| 8‑Apr‑2024 | Monte Carlo Masters | Clay | R32 | 2 | 27 | (2)Sinner d. Sebastian Korda [USA] | 6-1 6-2 | (ch) | 2.08 | 4.7% | 2.3% | 48.8% | 95.2% | 54.5% | 3/3 | 1:15 |
