| 22‑Oct‑2018 | Basel | Hard | R16 | 43 | 20 | (7)Daniil Medvedev [RUS] d. Seppi | 7-6(5) 6-2 | | 0.77 | 1.4% | 4.1% | 44.6% | 69.7% | 46.3% | 5/8 | 1:37 |
| 22‑Oct‑2018 | Basel | Hard | R32 | 43 | 74 | Seppi d. (Q)Taro Daniel [JPN] | 6-0 6-4 | | 1.78 | 4.7% | 2.3% | 60.5% | 73.1% | 64.7% | 0/1 | 1:03 |
| 26‑Oct‑2015 | Basel | Hard | R32 | 27 | 17 | (8)David Goffin [BEL] d. Seppi | 3-6 6-4 6-4 | | 1.00 | 4.3% | 4.3% | 51.1% | 68.8% | 45.7% | 10/15 | |
| 21‑Oct‑2013 | Basel | Hard | R32 | 27 | 58 | Daniel Brands [GER] d. (7)Seppi | 7-6(3) 6-3 | | 0.81 | 6.5% | 5.2% | 53.2% | 82.9% | 47.2% | 8/9 | 1:29 |
| 22‑Oct‑2012 | Basel | Hard | R32 | 22 | 46 | Benoit Paire [FRA] d. (5)Seppi | 4-6 6-2 6-3 | | 0.88 | 6.9% | 2.8% | 56.9% | 78.0% | 32.3% | 1/6 | 1:32 |
| 31‑Oct‑2011 | Basel | Hard | R16 | 50 | 32 | (WC)Kei Nishikori [JPN] d. Seppi | 6-3 7-6(4) | | 0.92 | 8.9% | 1.8% | 57.1% | 65.6% | 54.2% | 2/5 | 1:46 |
| 31‑Oct‑2011 | Basel | Hard | R32 | 50 | 51 | Seppi d. Gilles Muller [LUX] | 7-6(4) 6-7(5) 6-2 | | 1.17 | 12.4% | 1.9% | 49.5% | 82.7% | 58.5% | 2/3 | 2:23 |
| 2‑Nov‑2009 | Basel | Hard | R16 | 51 | 1 | (1)Roger Federer [SUI] d. Seppi | 6-3 6-3 | | 0.66 | 3.6% | 1.8% | 66.1% | 62.2% | 52.6% | 4/7 | 1:01 |
| 2‑Nov‑2009 | Basel | Hard | R32 | 51 | 148 | Seppi d. (WC)Stephane Bohli [SUI] | 4-6 6-1 7-5 | | 1.13 | 6.4% | 6.4% | 56.4% | 67.9% | 48.8% | 4/7 | 2:31 |
| 24‑Oct‑2005 | Basel | Carpet | R32 | 67 | 17 | (4)Fernando Gonzalez [CHI] d. Seppi | 7-6(3) 6-3 | | 0.92 | 3.1% | 10.8% | 61.5% | 72.5% | 40.0% | 3/6 | 1:14 |
