| 24‑Feb‑2025 | Dubai | Hard | QF | 30 | 11 | (4)Stefanos Tsitsipas [GRE] d. Berrettini | 7-6(5) 1-6 6-4 | (ch) | 1.34 | 7.5% | 0.0% | 77.5% | 79.0% | 77.8% | 3/4 | 1:57 |
| 13‑Jan‑2025 | Australian Open | Hard | R128 | 34 | 52 | Berrettini d. Cameron Norrie [GBR] | 6-7(4) 6-4 6-1 6-3 | | 1.51 | 28.1% | 6.1% | 70.2% | 85.0% | 47.1% | 5/5 | 2:56 |
| 11‑Sep‑2024 | Davis Cup Finals RR: ITA vs BRA | Hard | RR | 43 | 158 | Berrettini d. Joao Fonseca [BRA] | 6-1 7-6(5) | (ch) | 1.37 | 15.9% | 3.2% | 68.3% | 81.4% | 40.0% | 1/2 | 1:22 |
| 15‑Jul‑2024 | Gstaad | Clay | F | 82 | 192 | (6)Berrettini d. (Q)Quentin Halys [FRA] | 6-3 6-1 | (ch) | 4.52 | 2.7% | 2.7% | 78.4% | 89.7% | 87.5% | 3/3 | 0:59 |
| 1‑Jul‑2024 | Wimbledon | Grass | R128 | 59 | 70 | Berrettini d. Marton Fucsovics [HUN] | 7-6(3) 6-2 3-6 6-1 | (ch) | 1.44 | 9.9% | 0.0% | 65.8% | 80.8% | 57.9% | 9/10 | 2:56 |
| 10‑Jun‑2024 | Stuttgart | Grass | SF | 95 | 30 | (PR)Berrettini d. (5)Lorenzo Musetti [ITA] | 6-4 6-0 | (ch) | 1.67 | 12.8% | 2.1% | 68.1% | 78.1% | 60.0% | 4/4 | 1:06 |
| 1‑Apr‑2024 | Marrakech | Clay | R32 | 135 | 56 | (PR)Berrettini d. (6)Alexander Shevchenko [KAZ] | 6-2 6-1 | | 1.71 | 6.7% | 4.4% | 55.6% | 84.0% | 50.0% | 2/2 | 1:14 |
| 6‑Mar‑2023 | Indian Wells Masters | Hard | R64 | 23 | 103 | (Q)Taro Daniel [JPN] d. (20)Berrettini | 7-6(5) 0-6 6-3 | | 1.14 | 9.9% | 1.1% | 54.9% | 78.0% | 43.9% | 5/7 | 2:39 |
| 27‑Feb‑2023 | Acapulco | Hard | R32 | 24 | 57 | Berrettini d. Alex Molcan [SVK] | 6-0 1-0 RET | | 9.45 | 31.3% | 6.3% | 62.5% | 100.0% | 83.3% | 0/0 | 0:45 |
| 14‑Sep‑2022 | Davis Cup Finals RR: ITA vs CRO | Hard | RR | 15 | 26 | Berrettini d. Borna Coric [CRO] | 6-7(4) 6-2 6-1 | | | | | | | | | |
| 29‑Aug‑2022 | US Open | Hard | R64 | 14 | 119 | (13)Berrettini d. Hugo Grenier [FRA] | 2-6 6-1 7-6(4) 7-6(7) | | 1.50 | 14.5% | 2.6% | 47.9% | 87.5% | 67.2% | 2/4 | 3:25 |
| 18‑Jul‑2022 | Gstaad | Clay | SF | 15 | 274 | (2)Berrettini d. (PR)Dominic Thiem [AUT] | 6-1 6-4 | (ch) | 1.67 | 7.8% | 5.9% | 66.7% | 85.3% | 41.2% | 3/4 | 1:17 |
| 18‑Jul‑2022 | Gstaad | Clay | QF | 15 | 52 | (2)Berrettini d. (5)Pedro Martinez [ESP] | 3-6 7-6(5) 6-1 | | 1.26 | 18.5% | 6.2% | 56.8% | 82.6% | 57.1% | 2/3 | 2:16 |
| 17‑Jan‑2022 | Australian Open | Hard | R64 | 7 | 169 | (7)Berrettini d. (WC)Stefan Kozlov [USA] | 6-1 4-6 6-4 6-1 | | 1.63 | 21.0% | 1.0% | 70.0% | 78.6% | 56.7% | 4/5 | 2:38 |
| 28‑Jun‑2021 | Wimbledon | Grass | SF | 9 | 18 | (7)Berrettini d. (14)Hubert Hurkacz [POL] | 6-3 6-0 6-7(3) 6-4 | (ch) | 1.70 | 21.4% | 1.0% | 63.1% | 86.2% | 60.5% | 2/2 | 2:37 |
| 28‑Jun‑2021 | Wimbledon | Grass | R16 | 9 | 79 | (7)Berrettini d. Ilya Ivashka [BLR] | 6-4 6-3 6-1 | | 1.72 | 9.7% | 4.2% | 52.8% | 84.2% | 58.8% | 0/1 | 1:47 |
| 28‑Jun‑2021 | Wimbledon | Grass | R128 | 9 | 59 | (7)Berrettini d. Guido Pella [ARG] | 6-4 3-6 6-4 6-0 | | 1.64 | 22.7% | 3.4% | 61.4% | 83.3% | 61.8% | 0/1 | 2:16 |
| 31‑May‑2021 | Roland Garros | Clay | R128 | 9 | 113 | (9)Berrettini d. (Q)Taro Daniel [JPN] | 6-0 6-4 4-6 6-4 | | 2.15 | 16.5% | 4.7% | 69.4% | 89.8% | 61.5% | 0/1 | 2:22 |
| 3‑May‑2021 | Madrid Masters | Clay | QF | 10 | 25 | (8)Berrettini d. (16)Cristian Garin [CHI] | 5-7 6-3 6-0 | | 1.37 | 17.5% | 2.5% | 67.5% | 79.6% | 42.3% | 3/6 | 2:06 |
| 19‑Apr‑2021 | Belgrade | Clay | F | 10 | 28 | (2)Berrettini d. (3)Aslan Karatsev [RUS] | 6-1 3-6 7-6(0) | (ch) | 1.50 | 11.5% | 3.8% | 60.3% | 80.9% | 54.8% | 1/3 | 2:27 |
| 19‑Apr‑2021 | Belgrade | Clay | SF | 10 | 126 | (2)Berrettini d. (LL)Taro Daniel [JPN] | 6-1 6-7(5) 6-0 | | 1.81 | 13.0% | 2.6% | 67.5% | 78.8% | 60.0% | 1/2 | 2:07 |
| 5‑Jan‑2021 | Antalya | Hard | R32 | 10 | 446 | (1)Berrettini d. (WC)Ergi Kirkin [TUR] | 6-0 6-4 | | 2.84 | 20.5% | 5.1% | 66.7% | 92.3% | 61.5% | 0/0 | 0:56 |
| 28‑Sep‑2020 | Roland Garros | Clay | R128 | 8 | 76 | (7)Berrettini d. Vasek Pospisil [CAN] | 6-3 6-1 6-3 | | 2.07 | 6.3% | 3.1% | 57.8% | 78.4% | 74.1% | 1/1 | 1:48 |
| 14‑Sep‑2020 | Rome Masters | Clay | R32 | 8 | 104 | (4)Berrettini d. (Q)Federico Coria [ARG] | 7-5 6-1 | | 2.26 | 14.6% | 4.2% | 70.8% | 91.2% | 50.0% | 0/1 | 1:20 |
| 31‑Aug‑2020 | US Open | Hard | R128 | 8 | 119 | (6)Berrettini d. Go Soeda [JPN] | 7-6(5) 6-1 6-4 | | 2.44 | 23.1% | 0.0% | 64.1% | 94.0% | 67.9% | 4/4 | 2:01 |
| 20‑Jan‑2020 | Australian Open | Hard | R128 | 8 | 162 | (8)Berrettini d. (WC)Andrew Harris [AUS] | 6-3 6-1 6-3 | | 1.51 | 14.1% | 6.4% | 50.0% | 84.6% | 56.4% | 2/2 | 1:54 |
| 7‑Oct‑2019 | Shanghai Masters | Hard | R64 | 13 | 38 | (11)Berrettini d. Jan Lennard Struff [GER] | 6-2 6-1 | (ch) | 2.09 | 15.0% | 0.0% | 77.5% | 77.4% | 66.7% | 2/2 | 1:01 |
| 16‑Sep‑2019 | St. Petersburg | Hard | R16 | 13 | 77 | (3)Berrettini d. Roberto Carballes Baena [ESP] | 6-1 6-2 | (ch) | 3.23 | 13.2% | 0.0% | 68.4% | 88.5% | 75.0% | 0/0 | 0:56 |
| 26‑Aug‑2019 | US Open | Hard | R16 | 25 | 43 | (24)Berrettini d. Andrey Rublev [RUS] | 6-1 6-4 7-6(6) | | 1.46 | 7.5% | 1.1% | 62.4% | 84.5% | 48.6% | 2/3 | 2:11 |
| 26‑Aug‑2019 | US Open | Hard | R64 | 25 | 55 | (24)Berrettini d. Jordan Thompson [AUS] | 7-5 7-6(5) 4-6 6-1 | | 1.41 | 11.1% | 4.3% | 56.4% | 86.4% | 56.9% | 2/5 | 2:57 |
| 1‑Jul‑2019 | Wimbledon | Grass | R64 | 20 | 135 | (17)Berrettini d. Marcos Baghdatis [CYP] | 6-1 7-6(4) 6-3 | (ch) | 1.94 | 20.3% | 3.8% | 69.6% | 85.5% | 66.7% | 0/1 | 1:42 |
| 22‑Apr‑2019 | Budapest | Clay | F | 55 | 105 | Berrettini d. (Q)Filip Krajinovic [SRB] | 4-6 6-3 6-1 | (ch) | 2.09 | 9.7% | 1.6% | 50.0% | 83.9% | 77.4% | 1/2 | 1:41 |
| 30‑Jul‑2018 | Kitzbuhel | Clay | R16 | 54 | 98 | Berrettini d. Radu Albot [MDA] | 6-3 6-7(3) 6-1 | | 1.24 | 5.3% | 2.1% | 65.3% | 79.0% | 51.5% | 4/5 | 1:57 |
| 28‑May‑2018 | Roland Garros | Clay | R128 | 96 | 156 | Berrettini d. (LL)Oscar Otte [GER] | 3-6 7-5 6-2 6-1 | | 1.76 | 4.4% | 2.2% | 64.8% | 86.4% | 62.5% | 1/2 | 1:58 |
