| 6‑Nov‑2023 | Metz | Hard | R32 | 53 | 81 | (8)Wawrinka d. Bernabe Zapata Miralles [ESP] | 6-0 6-2 | | 2.87 | 8.6% | 2.9% | 57.1% | 80.0% | 80.0% | 0/0 | 0:51 |
| 27‑May‑2019 | Roland Garros | Clay | R64 | 28 | 37 | (24)Wawrinka d. Cristian Garin [CHI] | 6-1 6-4 6-0 | (ch) | 1.60 | 9.1% | 1.3% | 57.1% | 72.7% | 63.6% | 5/5 | 1:40 |
| 15‑Apr‑2019 | Monte Carlo Masters | Clay | R32 | 36 | 16 | (11)Marco Cecchinato [ITA] d. Wawrinka | 0-6 7-5 6-3 | | 1.07 | 7.2% | 2.9% | 52.2% | 69.4% | 54.5% | 0/3 | 1:44 |
| 29‑May‑2017 | Roland Garros | Clay | R32 | 3 | 29 | (3)Wawrinka d. (28)Fabio Fognini [ITA] | 7-6(2) 6-0 6-2 | | 1.54 | 7.6% | 2.5% | 62.0% | 73.5% | 60.0% | 4/6 | 1:51 |
| 31‑Aug‑2015 | US Open | Hard | QF | 5 | 14 | (5)Wawrinka d. (15)Kevin Anderson [RSA] | 6-4 6-4 6-0 | | 2.23 | 9.1% | 3.0% | 48.5% | 93.8% | 67.6% | 1/1 | |
| 10‑Aug‑2014 | Cincinnati Masters | Hard | R16 | 4 | 19 | (3)Wawrinka d. (14)Marin Cilic [CRO] | 3-6 6-0 6-1 | | 1.39 | 10.4% | 7.5% | 46.3% | 83.9% | 55.6% | 3/4 | 1:23 |
| 11‑May‑2014 | Rome Masters | Clay | R32 | 3 | 98 | (3)Wawrinka d. (Q)Pere Riba [ESP] | 6-0 6-3 | | 2.62 | 7.3% | 0.0% | 61.0% | 96.0% | 56.3% | 1/1 | 0:51 |
| 13‑Apr‑2014 | Monte Carlo Masters | Clay | R32 | 3 | 27 | (3)Wawrinka d. Marin Cilic [CRO] | 6-0 6-2 | | 3.31 | 8.8% | 2.9% | 67.6% | 78.3% | 90.9% | 0/0 | 0:46 |
| 19‑Mar‑2014 | Miami Masters | Hard | R64 | 3 | 99 | (3)Wawrinka d. Daniel Gimeno Traver [ESP] | 6-0 3-6 6-3 | | 1.40 | 9.6% | 3.6% | 59.0% | 81.6% | 44.1% | 4/6 | 1:29 |
| 6‑Mar‑2014 | Indian Wells Masters | Hard | R32 | 3 | 32 | (3)Wawrinka d. (29)Andreas Seppi [ITA] | 6-0 6-2 | | 2.52 | 18.4% | 7.9% | 57.9% | 86.4% | 62.5% | 0/0 | 0:49 |
| 8‑Jul‑2011 | Davis Cup G1 R2: SUI vs POR | Hard | RR | 15 | 311 | Wawrinka d. Leonardo Tavares [POR] | 7-6(1) 6-0 | | | | | | | | | |
| 21‑Feb‑2011 | Acapulco | Clay | R32 | 15 | 67 | (4)Wawrinka d. Pablo Andujar [ESP] | 7-6(5) 3-6 6-0 | | 1.07 | 3.1% | 3.1% | 59.2% | 65.5% | 55.0% | 9/13 | 2:03 |
| 10‑May‑2009 | Madrid Masters | Clay | R64 | 18 | 188 | (11)Wawrinka d. (Q)Marco Crugnola [ITA] | 6-2 6-0 | | 2.10 | 5.3% | 5.3% | 65.8% | 72.0% | 69.2% | 4/5 | 0:59 |
| 25‑Aug‑2008 | US Open | Hard | R32 | 10 | 142 | (10)Wawrinka d. (LL)Flavio Cipolla [ITA] | 5-7 6-7(4) 6-4 6-0 6-4 | | 1.16 | 6.5% | 1.3% | 51.0% | 71.8% | 48.0% | 8/15 | 4:11 |
| 21‑Jul‑2008 | Canada Masters | Hard | R16 | 10 | 9 | (8)Andy Murray [GBR] d. (9)Wawrinka | 6-2 0-6 6-4 | | 0.91 | 7.6% | 1.3% | 77.2% | 63.9% | 44.4% | 5/8 | 1:54 |
| 13‑Mar‑2008 | Indian Wells Masters | Hard | R32 | 35 | 18 | Wawrinka d. (18)Marcos Baghdatis [CYP] | 6-3 6-7(1) 6-0 | | 1.36 | 6.2% | 3.7% | 50.6% | 80.5% | 52.5% | 1/3 | 2:09 |
| 31‑Dec‑2007 | Doha | Hard | QF | 36 | 42 | Wawrinka d. Agustin Calleri [ARG] | 6-3 6-0 | | 2.93 | 10.3% | 0.0% | 59.0% | 87.0% | 75.0% | 0/0 | 1:05 |
| 28‑Aug‑2006 | US Open | Hard | R64 | 46 | 34 | Wawrinka d. Robin Soderling [SWE] | 6-7(4) 2-6 7-6(4) 6-0 6-1 | | 1.23 | 14.1% | 2.5% | 61.3% | 77.0% | 54.0% | 9/11 | 3:12 |
| 16‑Jan‑2006 | Australian Open | Hard | R128 | 46 | 72 | Wawrinka d. Albert Montanes [ESP] | 4-6 6-2 6-3 6-0 | | 1.29 | 9.9% | 5.9% | 53.5% | 85.2% | 51.1% | 1/2 | 1:48 |
