| 26‑Aug‑2024 | US Open | Hard | R32 | 8 | 72 | (8)Ruud d. Juncheng Shang [CHN] | 6-7(1) 3-6 6-0 6-3 6-1 | | 1.18 | 6.6% | 4.6% | 64.9% | 67.3% | 52.8% | 14/17 | 3:44 |
| 6‑May‑2024 | Rome Masters | Clay | R64 | 7 | 58 | Miomir Kecmanovic [SRB] d. (5)Ruud | 0-6 6-4 6-4 | (ch) | 1.06 | 6.7% | 5.6% | 54.4% | 63.3% | 51.2% | 10/14 | 2:19 |
| 19‑Feb‑2024 | Los Cabos | Hard | R16 | 12 | 44 | (4)Ruud d. Marcos Giron [USA] | 6-1 6-0 | | 1.91 | 6.7% | 0.0% | 57.8% | 73.1% | 52.6% | 2/3 | 1:02 |
| 2‑Oct‑2023 | Shanghai Masters | Hard | R64 | 9 | 48 | (8)Ruud d. Yoshihito Nishioka [JPN] | 7-5 6-0 | (ch) | 2.97 | 23.1% | 0.0% | 87.2% | 85.3% | 60.0% | 0/1 | 1:14 |
| 28‑Aug‑2023 | US Open | Hard | R64 | 5 | 67 | Zhizhen Zhang [CHN] d. (5)Ruud | 6-4 5-7 6-2 0-6 6-2 | (ch) | 0.83 | 4.8% | 1.4% | 64.1% | 69.9% | 46.2% | 12/17 | 3:19 |
| 29‑May‑2023 | Roland Garros | Clay | SF | 4 | 27 | (4)Ruud d. (22)Alexander Zverev [GER] | 6-3 6-4 6-0 | (ch) | 1.33 | 5.6% | 1.1% | 61.8% | 70.9% | 52.9% | 8/9 | 2:09 |
| 8‑May‑2023 | Rome Masters | Clay | R64 | 4 | 89 | (4)Ruud d. Arthur Rinderknech [FRA] | 6-4 6-0 | (ch) | 1.99 | 2.2% | 4.4% | 73.3% | 81.8% | 58.3% | 2/2 | 1:01 |
| 3‑Apr‑2023 | Estoril | Clay | QF | 5 | 32 | (1)Ruud d. (5)Sebastian Baez [ARG] | 6-3 6-0 | | 1.42 | 3.4% | 5.1% | 67.8% | 67.5% | 52.6% | 6/7 | 1:18 |
| 29‑Aug‑2022 | US Open | Hard | R32 | 7 | 34 | (5)Ruud d. (29)Tommy Paul [USA] | 7-6(3) 6-7(5) 7-6(2) 5-7 6-0 | (ch) | 1.17 | 2.5% | 3.1% | 61.3% | 71.4% | 58.1% | 1/6 | 4:23 |
| 18‑Jul‑2022 | Gstaad | Clay | SF | 5 | 40 | (1)Ruud d. (4)Albert Ramos [ESP] | 6-2 6-0 | (ch) | 1.91 | 2.3% | 4.7% | 60.5% | 80.8% | 52.9% | 0/0 | 1:02 |
| 1‑Nov‑2021 | Paris Masters | Hard | R32 | 8 | 36 | (6)Ruud d. Alexander Bublik [KAZ] | 6-4 6-0 | (ch) | 1.52 | 3.9% | 3.9% | 51.0% | 69.2% | 56.0% | 4/6 | 1:17 |
| 27‑Sep‑2021 | San Diego | Hard | F | 10 | 28 | (2)Ruud d. Cameron Norrie [GBR] | 6-0 6-2 | (ch) | 1.99 | 2.4% | 0.0% | 65.9% | 74.1% | 64.3% | 0/0 | 1:01 |
| 16‑Aug‑2021 | Cincinnati Masters | Hard | R32 | 11 | 23 | (8)Ruud d. Reilly Opelka [USA] | 6-7(5) 6-0 7-6(4) | | 1.27 | 21.9% | 2.1% | 71.9% | 87.0% | 44.4% | 3/3 | 2:25 |
| 19‑Jul‑2021 | Gstaad | Clay | SF | 14 | 249 | (3)Ruud d. (Q)Vit Kopriva [CZE] | 6-3 6-0 | | 2.06 | 4.9% | 0.0% | 68.3% | 78.6% | 61.5% | 0/1 | 1:14 |
| 12‑Jul‑2021 | Bastad | Clay | R16 | 16 | 211 | (1)Ruud d. (WC)Holger Rune [DEN] | 6-0 6-2 | | 2.33 | 13.3% | 2.2% | 66.7% | 86.7% | 46.7% | 3/3 | 1:05 |
| 31‑May‑2021 | Roland Garros | Clay | R32 | 16 | 46 | Alejandro Davidovich Fokina [ESP] d. (15)Ruud | 7-6(3) 2-6 7-6(6) 0-6 7-5 | (ch) | 1.14 | 3.6% | 3.6% | 64.2% | 63.2% | 57.6% | 10/14 | 4:35 |
| 10‑Feb‑2020 | Buenos Aires | Clay | R16 | 45 | 88 | (8)Ruud d. Roberto Carballes Baena [ESP] | 6-1 6-0 | | 2.34 | 7.9% | 5.3% | 73.7% | 75.0% | 70.0% | 0/0 | 0:57 |
| 13‑Sep‑2019 | Davis Cup G2 R1: NOR vs GEO | Clay | RR | 60 | 933 | Ruud d. George Tsivadze [GEO] | 6-1 6-0 | | | | | | | | | |
| 27‑May‑2019 | Roland Garros | Clay | R128 | 63 | 79 | Ruud d. Ernests Gulbis [LAT] | 6-2 7-6(2) 6-0 | | 1.86 | 7.8% | 6.5% | 72.7% | 80.4% | 57.1% | 5/6 | 2:13 |
| 8‑Apr‑2019 | Houston | Clay | QF | 95 | 112 | Ruud d. Marcel Granollers [ESP] | 6-1 6-0 | | 2.08 | 0.0% | 4.4% | 68.9% | 71.0% | 71.4% | 2/2 | 1:02 |
| 16‑Jul‑2018 | Bastad | Clay | R32 | 147 | 90 | (WC)Ruud d. (WC)Jaume Munar [ESP] | 6-7(7) 6-4 6-0 | | 1.29 | 11.0% | 4.0% | 74.0% | 73.0% | 50.0% | 6/7 | 2:38 |
| 5‑Feb‑2018 | Quito | Clay | R32 | 122 | 119 | Ruud d. Carlos Berlocq [ARG] | 7-5 6-0 | | 1.56 | 7.1% | 7.1% | 66.1% | 81.1% | 47.4% | 0/0 | 1:32 |
| 8‑Jan‑2018 | Auckland | Hard | R32 | 137 | 43 | Robin Haase [NED] d. (Q)Ruud | 0-6 7-6(6) 6-3 | | 1.27 | 15.0% | 3.8% | 70.0% | 82.1% | 50.0% | 1/2 | 1:40 |
