| 17‑Apr‑2023 | Munich | Clay | R16 | 29 | 129 | (4)Van De Zandschulp d. (Q)Aslan Karatsev [RUS] | 6-2 6-0 | | 1.71 | 5.9% | 7.8% | 51.0% | 80.8% | 52.0% | 6/6 | 1:08 |
| 17‑Jan‑2022 | Australian Open | Hard | R64 | 57 | 81 | Van De Zandschulp d. Richard Gasquet [FRA] | 4-6 6-0 4-0 RET | | 1.68 | 28.1% | 1.8% | 70.2% | 72.5% | 64.7% | 4/5 | 1:25 |
| 18‑Oct‑2021 | Antwerp | Hard | R32 | 61 | 74 | Van De Zandschulp d. Alexei Popyrin [AUS] | 6-4 3-6 6-0 | | 1.58 | 12.5% | 3.1% | 64.1% | 90.2% | 47.8% | 2/3 | 1:36 |
| 18‑Sep‑2021 | Davis Cup WG1 R1: NED vs URU | Clay | RR | 62 | 1262 | Van De Zandschulp d. Francisco Llanes [URU] | 6-0 6-3 | (ch) | 1.97 | 5.0% | 10.0% | 72.5% | 79.3% | 36.4% | 1/2 | 1:09 |
| 30‑Aug‑2021 | US Open | Hard | R32 | 117 | 80 | (Q)Van De Zandschulp d. Facundo Bagnis [ARG] | 3-6 6-0 6-2 6-2 | (ch) | 1.35 | 10.5% | 4.8% | 57.1% | 85.0% | 37.8% | 7/9 | 2:30 |