| 1‑Jul‑2024 | Wimbledon | Grass | QF | 12 | 25 | (25)Lorenzo Musetti [ITA] d. (13)Fritz | 3-6 7-6(5) 6-2 3-6 6-1 | (ch) | 0.86 | 6.9% | 0.7% | 61.1% | 64.8% | 57.1% | 7/13 | 3:27 |
| 28‑Aug‑2023 | US Open | Hard | QF | 9 | 2 | (2)Novak Djokovic [SRB] d. (9)Fritz | 6-1 6-4 6-4 | (ch) | 0.77 | 9.0% | 2.2% | 55.1% | 73.5% | 27.5% | 3/9 | 2:35 |
| 7‑Aug‑2023 | Canada Masters | Hard | R16 | 9 | 18 | Alex De Minaur [AUS] d. (8)Fritz | 7-6(7) 4-6 6-1 | | 0.85 | 13.2% | 0.9% | 59.4% | 66.7% | 46.5% | 4/8 | 2:26 |
| 8‑May‑2023 | Rome Masters | Clay | R64 | 9 | 101 | (Q)Yannick Hanfmann [GER] d. (9)Fritz | 6-4 6-1 | (ch) | 0.52 | 1.9% | 3.8% | 45.3% | 54.2% | 41.4% | 0/5 | 1:11 |
| 10‑Apr‑2023 | Monte Carlo Masters | Clay | SF | 10 | 6 | (5)Andrey Rublev [RUS] d. (8)Fritz | 5-7 6-1 6-3 | (ch) | 0.82 | 5.2% | 6.3% | 49.0% | 63.8% | 34.7% | 13/21 | 2:07 |
| 24‑Oct‑2022 | Vienna | Hard | R16 | 10 | 19 | Denis Shapovalov [CAN] d. (4)Fritz | 6-1 4-6 6-3 | (ch) | 0.55 | 12.3% | 1.2% | 63.0% | 72.5% | 40.0% | 2/6 | 1:42 |
| 15‑Sep‑2022 | Davis Cup Finals RR: USA vs KAZ | Hard | RR | 12 | 44 | Fritz d. Alexander Bublik [KAZ] | 7-6(6) 1-6 6-3 | | | | | | | | | |
| 21‑Mar‑2022 | Miami Masters | Hard | R16 | 13 | 48 | Miomir Kecmanovic [SRB] d. (11)Fritz | 3-6 6-1 6-4 | | 0.96 | 9.1% | 1.1% | 68.2% | 70.0% | 50.0% | 5/8 | 2:06 |
| 30‑Aug‑2021 | US Open | Hard | R128 | 42 | 17 | Fritz d. (14)Alex De Minaur [AUS] | 7-6(4) 6-2 1-6 6-4 | | 1.02 | 8.2% | 4.9% | 57.4% | 65.7% | 53.8% | 9/13 | 3:02 |
| 19‑Jul‑2021 | Los Cabos | Hard | SF | 37 | 30 | (1)Cameron Norrie [GBR] d. (3)Fritz | 6-3 6-1 | | 0.44 | 14.9% | 4.3% | 53.2% | 76.0% | 18.2% | 2/6 | 1:10 |
| 5‑Apr‑2021 | Cagliari | Clay | SF | 30 | 34 | (3)Lorenzo Sonego [ITA] d. (2)Fritz | 6-4 5-7 6-1 | | 0.89 | 2.8% | 0.9% | 56.0% | 55.7% | 39.6% | 10/18 | 2:38 |
| 15‑Mar‑2021 | Dubai | Hard | R16 | 30 | 8 | (2)Andrey Rublev [RUS] d. (15)Fritz | 6-3 6-1 | (ch) | 0.52 | 10.0% | 6.7% | 43.3% | 73.1% | 29.4% | 2/6 | 1:04 |
| 8‑Mar‑2021 | Doha | Hard | SF | 33 | 42 | Nikoloz Basilashvili [GEO] d. Fritz | 7-6(3) 6-1 | | 0.68 | 12.5% | 1.6% | 64.1% | 68.3% | 43.5% | 4/7 | 1:15 |
| 28‑Sep‑2020 | Roland Garros | Clay | R128 | 30 | 253 | (27)Fritz d. (Q)Tomas Machac [CZE] | 7-5 7-6(2) 1-6 2-6 6-3 | | 1.03 | 9.4% | 2.7% | 59.1% | 71.6% | 37.7% | 5/14 | 3:39 |
| 6‑Jan‑2020 | Atp Cup | Hard | RR | 31 | 17 | Karen Khachanov [RUS] d. Fritz | 3-6 7-5 6-1 | (ch) | 0.73 | 12.4% | 6.7% | 59.6% | 79.2% | 30.6% | 3/7 | 1:51 |
| 20‑Aug‑2018 | Winston-Salem | Hard | R32 | 70 | 32 | (7)Filip Krajinovic [SRB] d. (WC)Fritz | 6-4 6-1 | | 0.53 | 4.5% | 4.5% | 52.2% | 62.9% | 43.8% | 8/12 | 1:03 |
| 30‑Jul‑2018 | Los Cabos | Hard | R16 | 65 | 247 | (PR)Yoshihito Nishioka [JPN] d. (7)Fritz | 7-6(3) 6-1 | | 0.85 | 17.5% | 1.6% | 66.7% | 71.4% | 19.0% | 3/7 | 1:25 |
| 2‑Jul‑2018 | Wimbledon | Grass | R64 | 68 | 3 | (4)Alexander Zverev [GER] d. Fritz | 6-4 5-7 6-7(0) 6-1 6-2 | (ch) | 0.80 | 8.6% | 6.0% | 55.0% | 85.5% | 35.3% | 11/16 | 3:12 |
| 21‑May‑2018 | Lyon | Clay | QF | 70 | 68 | Dusan Lajovic [SRB] d. Fritz | 7-5 6-1 | | 0.47 | 3.3% | 3.3% | 62.3% | 68.4% | 21.7% | 7/12 | 1:01 |
| 15‑Aug‑2016 | Cincinnati Masters | Hard | R64 | 54 | 68 | (Q)Mikhail Youzhny [RUS] d. (WC)Fritz | 6-1 6-3 | | 0.57 | 7.1% | 1.8% | 48.2% | 66.7% | 41.4% | 1/5 | 1:12 |
| 27‑Jun‑2016 | Wimbledon | Grass | R128 | 65 | 5 | (4)Stan Wawrinka [SUI] d. Fritz | 7-6(4) 6-1 6-7(2) 6-4 | | 0.59 | 3.9% | 1.9% | 58.4% | 66.7% | 46.9% | 7/12 | 2:23 |
| 23‑May‑2016 | Roland Garros | Clay | R128 | 67 | 47 | Borna Coric [CRO] d. Fritz | 6-3 6-1 6-3 | | 0.51 | 6.6% | 1.9% | 60.4% | 56.3% | 40.5% | 13/20 | 1:44 |
| 21‑Mar‑2016 | Miami Masters | Hard | R64 | 81 | 8 | (8)David Ferrer [ESP] d. (Q)Fritz | 7-6(6) 6-1 | | 0.73 | 6.5% | 5.4% | 57.0% | 64.2% | 35.0% | 13/16 | 1:47 |
