| 5‑Mar‑2025 | Indian Wells Masters | Hard | R64 | 85 | 7 | (LL)Van De Zandschulp d. (6)Novak Djokovic [SRB] | 6-2 3-6 6-1 | (ch) | 1.31 | 4.9% | 4.9% | 70.7% | 60.3% | 70.8% | 2/4 | 2:01 |
| 26‑Aug‑2024 | US Open | Hard | R64 | 74 | 3 | Van De Zandschulp d. (3)Carlos Alcaraz [ESP] | 6-1 7-5 6-4 | (ch) | 1.23 | 2.1% | 7.4% | 66.3% | 77.8% | 40.6% | 3/5 | 2:19 |
| 1‑Apr‑2024 | Estoril | Clay | R32 | 87 | 88 | Van De Zandschulp d. Federico Coria [ARG] | 6-4 4-6 6-1 | | 1.17 | 1.0% | 4.9% | 63.7% | 64.6% | 45.9% | 4/8 | 2:21 |
| 1‑Jan‑2024 | Hong Kong | Hard | R32 | 50 | 137 | Van De Zandschulp d. (WC)Shintaro Mochizuki [JPN] | 7-5 6-1 | | 1.29 | 4.2% | 4.2% | 59.2% | 71.4% | 48.3% | 10/12 | 1:37 |
| 2‑Oct‑2023 | Shanghai Masters | Hard | R64 | 67 | 34 | (32)Ugo Humbert [FRA] d. Van De Zandschulp | 6-4 1-6 6-2 | | 1.03 | 3.0% | 4.5% | 60.6% | 70.0% | 34.6% | 3/8 | 1:57 |
| 28‑Aug‑2023 | US Open | Hard | R64 | 65 | 28 | (26)Daniel Evans [GBR] d. Van De Zandschulp | 1-6 6-1 6-3 6-3 | | 0.68 | 5.6% | 6.5% | 57.0% | 67.2% | 43.5% | 8/13 | 2:41 |
| 17‑Apr‑2023 | Munich | Clay | F | 29 | 7 | (1)Holger Rune [DEN] d. (4)Van De Zandschulp | 6-4 1-6 7-6(3) | (ch) | 1.05 | 2.7% | 1.8% | 69.0% | 65.4% | 42.9% | 9/14 | 2:52 |
| 10‑Apr‑2023 | Monte Carlo Masters | Clay | R64 | 31 | 73 | Van De Zandschulp d. (Q)Marton Fucsovics [HUN] | 3-6 7-6(2) 6-1 | (ch) | 1.11 | 2.2% | 4.4% | 61.1% | 67.3% | 51.4% | 5/9 | 2:37 |
| 3‑Oct‑2022 | Astana | Hard | R32 | 34 | 327 | Van De Zandschulp d. (WC)Beibit Zhukayev [KAZ] | 6-1 6-1 | | 1.98 | 2.7% | 5.4% | 56.8% | 90.5% | 43.8% | 0/1 | 1:07 |
| 13‑Sep‑2022 | Davis Cup Finals RR: KAZ vs NED | Hard | RR | 35 | 44 | Van De Zandschulp d. Alexander Bublik [KAZ] | 3-6 6-1 6-4 | | | | | | | | | |
| 29‑Aug‑2022 | US Open | Hard | R64 | 22 | 112 | Corentin Moutet [FRA] d. (21)Van De Zandschulp | 6-4 1-6 6-2 6-4 | (ch) | 0.96 | 17.0% | 9.4% | 62.3% | 72.7% | 35.0% | 2/8 | 2:59 |
| 29‑Aug‑2022 | US Open | Hard | R128 | 22 | 126 | (21)Van De Zandschulp d. Tomas Machac [CZE] | 3-6 7-6(3) 6-1 3-6 7-5 | (ch) | 1.09 | 11.1% | 7.8% | 54.2% | 83.1% | 45.7% | 5/8 | 4:10 |
| 8‑Aug‑2022 | Canada Masters | Hard | R64 | 25 | 35 | Van De Zandschulp d. Miomir Kecmanovic [SRB] | 6-1 7-5 | | 1.93 | 24.5% | 4.1% | 69.4% | 85.3% | 60.0% | 4/5 | 1:05 |
| 27‑Jun‑2022 | Wimbledon | Grass | R32 | 25 | 69 | (21)Van De Zandschulp d. Richard Gasquet [FRA] | 7-5 2-6 7-6(7) 6-1 | | 1.31 | 17.5% | 7.0% | 62.3% | 84.5% | 44.2% | 2/6 | 2:38 |
| 27‑Jun‑2022 | Wimbledon | Grass | R64 | 25 | 49 | (21)Van De Zandschulp d. Emil Ruusuvuori [FIN] | 3-6 6-1 6-4 6-4 | | 1.33 | 8.7% | 4.8% | 58.7% | 83.6% | 53.5% | 3/4 | 2:23 |
| 13‑Jun‑2022 | Queen's Club | Grass | R32 | 29 | 227 | Van De Zandschulp d. (Q)Paul Jubb [GBR] | 7-6(5) 4-6 6-1 | | 1.09 | 5.5% | 6.4% | 64.5% | 69.0% | 48.7% | 11/14 | 2:36 |
| 9‑May‑2022 | Rome Masters | Clay | R64 | 32 | 30 | Van De Zandschulp d. Sebastian Korda [USA] | 6-4 6-1 | | 1.70 | 2.1% | 2.1% | 56.3% | 81.5% | 61.9% | 2/2 | 1:24 |
| 25‑Apr‑2022 | Munich | Clay | QF | 40 | 7 | (8)Van De Zandschulp d. (2)Casper Ruud [NOR] | 7-5 6-1 | (ch) | 1.90 | 8.2% | 0.0% | 69.4% | 73.5% | 80.0% | 1/1 | 1:33 |
| 7‑Feb‑2022 | Rotterdam | Hard | R16 | 51 | 137 | (Q)Jiri Lehecka [CZE] d. Van De Zandschulp | 1-6 6-4 6-4 | | 1.24 | 5.3% | 4.0% | 56.0% | 78.6% | 51.5% | 3/6 | 1:56 |
| 7‑Feb‑2022 | Rotterdam | Hard | R32 | 51 | 129 | Van De Zandschulp d. (Q)Bernabe Zapata Miralles [ESP] | 6-1 6-2 | | 1.64 | 12.2% | 7.3% | 61.0% | 76.0% | 37.5% | 3/5 | 1:05 |
| 30‑Aug‑2021 | US Open | Hard | R16 | 117 | 14 | (Q)Van De Zandschulp d. (11)Diego Schwartzman [ARG] | 6-3 6-4 5-7 5-7 6-1 | (ch) | 1.12 | 9.1% | 6.1% | 66.1% | 77.1% | 41.1% | 9/13 | 4:20 |
| 28‑Jun‑2021 | Wimbledon | Grass | R128 | 139 | 131 | (LL)Van De Zandschulp d. (Q)Gregoire Barrere [FRA] | 6-2 6-7(4) 6-1 7-6(3) | (ch) | 1.30 | 10.9% | 6.2% | 60.5% | 76.9% | 54.9% | 1/4 | 2:40 |