| 28‑Aug‑2017 | US Open | Hard | R64 | 3 | 101 | (3)Federer d. Mikhail Youzhny [RUS] | 6-1 6-7(3) 4-6 6-4 6-2 | | 1.39 | 8.6% | 1.4% | 62.1% | 78.2% | 50.9% | 4/8 | 3:08 |
| 23‑Feb‑2015 | Dubai | Hard | R32 | 2 | 55 | (2)Federer d. Mikhail Youzhny [RUS] | 6-3 6-1 | | 1.71 | 16.3% | 4.1% | 63.3% | 83.9% | 50.0% | 0/0 | 0:56 |
| 10‑Jun‑2013 | Halle | Grass | F | 3 | 29 | (1)Federer d. Mikhail Youzhny [RUS] | 6-7(5) 6-3 6-4 | (ch) | 1.39 | 11.3% | 1.0% | 66.0% | 79.7% | 66.7% | 2/2 | 2:03 |
| 25‑Jun‑2012 | Wimbledon | Grass | QF | 3 | 33 | (3)Federer d. (26)Mikhail Youzhny [RUS] | 6-1 6-2 6-2 | (ch) | 1.89 | 3.0% | 0.0% | 62.1% | 87.8% | 52.0% | 2/2 | 1:32 |
| 11‑Jun‑2012 | Halle | Grass | SF | 3 | 31 | (2)Federer d. Mikhail Youzhny [RUS] | 6-1 6-4 | | 1.81 | 17.0% | 0.0% | 68.1% | 84.4% | 46.7% | 3/4 | 1:00 |
| 27‑Feb‑2012 | Dubai | Hard | QF | 3 | 34 | (2)Federer d. Mikhail Youzhny [RUS] | 6-3 6-4 | | 1.58 | 9.3% | 0.0% | 53.7% | 69.0% | 80.0% | 0/0 | 1:10 |
| 13‑Feb‑2012 | Rotterdam | Hard | R16 | 3 | 31 | (1)Federer d. Mikhail Youzhny [RUS] | W/O | | | | | | | | | |
| 20‑Jun‑2011 | Wimbledon | Grass | R16 | 3 | 17 | (3)Federer d. (18)Mikhail Youzhny [RUS] | 6-7(5) 6-3 6-3 6-3 | | 1.53 | 12.3% | 0.9% | 62.3% | 84.5% | 51.2% | 6/7 | 3:02 |
| 28‑May‑2007 | Roland Garros | Clay | R16 | 1 | 15 | (1)Federer d. (13)Mikhail Youzhny [RUS] | 7-6(3) 6-4 6-4 | | 1.31 | 1.0% | 2.0% | 50.0% | 70.0% | 66.0% | 6/8 | 2:25 |
| 26‑Feb‑2007 | Dubai | Hard | F | 1 | 18 | (1)Federer d. Mikhail Youzhny [RUS] | 6-4 6-3 | (ch) | 1.53 | 7.8% | 0.0% | 56.9% | 79.3% | 54.5% | 0/2 | 1:25 |
| 15‑Jan‑2007 | Australian Open | Hard | R32 | 1 | 25 | (1)Federer d. (25)Mikhail Youzhny [RUS] | 6-3 6-3 7-6(5) | | 1.28 | 7.0% | 1.0% | 53.0% | 83.0% | 53.2% | 3/4 | 2:04 |
| 27‑Feb‑2006 | Dubai | Hard | SF | 1 | 52 | (1)Federer d. Mikhail Youzhny [RUS] | 6-2 6-3 | | 1.31 | 5.2% | 0.0% | 53.4% | 74.2% | 63.0% | 8/8 | 1:06 |
| 21‑Feb‑2005 | Dubai | Hard | QF | 1 | 17 | (1)Federer d. (7)Mikhail Youzhny [RUS] | 6-3 7-5 | | 1.15 | 4.2% | 1.4% | 58.3% | 81.0% | 46.7% | 0/1 | 1:13 |
| 7‑Jun‑2004 | Halle | Grass | R16 | 1 | 34 | (1)Federer d. Mikhail Youzhny [RUS] | 6-2 6-1 | | 1.78 | 7.1% | 0.0% | 61.9% | 73.1% | 62.5% | 0/1 | 1:09 |
| 9‑Jun‑2003 | Halle | Grass | SF | 5 | 29 | (1)Federer d. (6)Mikhail Youzhny [RUS] | 4-6 7-6(4) 6-2 | | 1.37 | 13.3% | 4.4% | 66.7% | 78.3% | 46.7% | 2/4 | 2:25 |
| 28‑Apr‑2003 | Munich | Clay | QF | 5 | 30 | (1)Federer d. (6)Mikhail Youzhny [RUS] | 6-2 6-3 | | 1.93 | 6.1% | 0.0% | 63.3% | 83.9% | 66.7% | 1/1 | 1:01 |
| 10‑Jun‑2002 | Halle | Grass | QF | 10 | 67 | (2)Federer d. Mikhail Youzhny [RUS] | 6-3 6-4 | | 1.21 | 15.5% | 1.7% | 72.4% | 78.6% | 50.0% | 1/2 | 0:59 |
| 20‑Nov‑2000 | Stockholm | Hard | R32 | 29 | 110 | (7)Federer d. Mikhail Youzhny [RUS] | 5-7 6-4 6-3 | | 1.12 | 10.4% | 2.1% | 63.5% | 72.1% | 54.3% | 5/8 | 1:51 |
