| 15‑Nov‑2010 | Champaign CH | Hard | R16 | 101 | 696 | (WC)Amer Delic [BIH] d. (1)Nishikori | 7-5 6-3 | | 0.88 | 3.0% | 4.5% | 53.7% | 69.4% | 48.4% | 5/8 | 1:28 |
| 15‑Nov‑2010 | Champaign CH | Hard | R32 | 101 | 377 | (1)Nishikori d. Chris Guccione [AUS] | 6-4 6-4 | | 0.98 | 7.7% | 7.7% | 69.2% | 80.0% | 35.0% | 1/2 | 1:05 |
| 8‑Nov‑2010 | Knoxville CH | Hard | F | 120 | 130 | (3)Nishikori d. (6)Robert Kendrick [USA] | 6-1 6-4 | | 1.43 | 1.7% | 0.0% | 63.8% | 78.4% | 57.1% | 0/0 | 1:05 |
| 8‑Nov‑2010 | Knoxville CH | Hard | SF | 120 | 427 | (3)Nishikori d. (Q)Nicholas Monroe [USA] | 6-1 7-6(4) | | 1.46 | 3.3% | 3.3% | 60.0% | 77.8% | 62.5% | 0/1 | 1:18 |
| 8‑Nov‑2010 | Knoxville CH | Hard | QF | 120 | 180 | (3)Nishikori d. Bobby Reynolds [USA] | 6-3 6-2 | | 1.65 | 10.5% | 1.8% | 70.2% | 80.0% | 52.9% | 3/3 | 1:13 |
| 8‑Nov‑2010 | Knoxville CH | Hard | R16 | 120 | | (3)Nishikori d. (Q)David Martin [USA] | 6-3 6-2 | | 1.79 | 18.4% | 0.0% | 77.6% | 84.2% | 45.5% | 0/0 | 0:58 |
| 8‑Nov‑2010 | Knoxville CH | Hard | R32 | 120 | | (3)Nishikori d. (WC)John Patrick Smith [AUS] | 6-4 6-1 | | 1.35 | 1.9% | 5.6% | 64.8% | 71.4% | 47.4% | 0/1 | 1:10 |
| 1‑Nov‑2010 | Charlottesville CH | Hard | QF | 126 | | (Q)Michael Shabaz [USA] d. (5)Nishikori | 7-6(3) 6-1 | | 0.73 | 7.3% | 7.3% | 60.0% | 63.6% | 50.0% | 3/6 | 1:14 |
| 1‑Nov‑2010 | Charlottesville CH | Hard | R16 | 126 | 502 | (5)Nishikori d. (WC)Theodoros Angelinos [GRE] | 6-4 6-2 | | 1.36 | 1.5% | 0.0% | 59.1% | 71.8% | 63.0% | 4/4 | 1:20 |
| 1‑Nov‑2010 | Charlottesville CH | Hard | R32 | 126 | 253 | (5)Nishikori d. Ryler Deheart [USA] | 7-5 7-5 | | 1.13 | 5.7% | 7.1% | 71.4% | 68.0% | 55.0% | 2/4 | 1:35 |
| 10‑Oct‑2010 | Shanghai Masters | Hard | Q1 | 119 | 61 | (3)Benjamin Becker [GER] d. Nishikori | 7-5 4-6 7-6(4) | | 0.88 | 2.3% | 3.1% | 69.0% | 71.9% | 47.5% | 8/10 | 2:46 |
| 4‑Oct‑2010 | Tokyo | Hard | R32 | 121 | 54 | Viktor Troicki [SRB] d. (WC)Nishikori | 6-4 6-2 | | 0.62 | 0.0% | 5.1% | 57.0% | 57.8% | 38.2% | 9/14 | 1:22 |
| 27‑Sep‑2010 | Kuala Lumpur | Hard | R32 | 123 | 18 | (6)Marcos Baghdatis [CYP] d. Nishikori | 6-1 6-1 | | 0.43 | 0.0% | 13.5% | 62.2% | 39.1% | 35.7% | 1/6 | 0:54 |
| 30‑Aug‑2010 | US Open | Hard | R32 | 147 | 23 | (21)Albert Montanes [ESP] d. (Q)Nishikori | 6-2 2-1 RET | | 0.45 | 0.0% | 8.1% | 54.1% | 55.0% | 41.2% | 4/7 | 0:38 |
| 30‑Aug‑2010 | US Open | Hard | R64 | 147 | 13 | (Q)Nishikori d. (11)Marin Cilic [CRO] | 5-7 7-6(6) 3-6 7-6(3) 6-1 | | 1.01 | 7.0% | 5.9% | 58.4% | 75.9% | 39.0% | 7/12 | 4:59 |
| 30‑Aug‑2010 | US Open | Hard | R128 | 147 | 69 | (Q)Nishikori d. Evgeny Korolev [KAZ] | 7-6(0) 5-2 RET | | 1.62 | 13.2% | 3.8% | 58.5% | 77.4% | 63.6% | 0/2 | 1:33 |
| 30‑Aug‑2010 | US Open | Hard | Q3 | 147 | 420 | (24)Nishikori d. Frank Dancevic [CAN] | 6-4 6-1 | | 1.69 | 3.8% | 3.8% | 65.4% | 79.4% | 50.0% | 4/5 | 1:02 |
| 30‑Aug‑2010 | US Open | Hard | Q2 | 147 | 196 | (24)Nishikori d. Alexander Kudryavtsev [RUS] | 6-3 7-6(1) | | 1.26 | 4.2% | 6.9% | 54.2% | 66.7% | 57.6% | 5/8 | 1:16 |
| 30‑Aug‑2010 | US Open | Hard | Q1 | 147 | 219 | (24)Nishikori d. Paul Capdeville [CHI] | 6-3 5-7 6-2 | | 1.11 | 5.3% | 8.8% | 59.6% | 67.6% | 52.2% | 8/11 | 2:22 |
| 9‑Aug‑2010 | Binghamton CH | Hard | F | 192 | 159 | (WC)Nishikori d. (8)Robert Kendrick [USA] | 6-3 7-6(4) | | 1.27 | 2.9% | 1.5% | 69.1% | 78.7% | 66.7% | 0/0 | 1:18 |
| 9‑Aug‑2010 | Binghamton CH | Hard | SF | 192 | 247 | (WC)Nishikori d. (Q)Alex Bogomolov Jr [RUS] | 7-6(4) 6-1 | | 1.34 | 4.1% | 0.0% | 59.5% | 75.0% | 60.0% | 2/3 | 1:39 |
| 9‑Aug‑2010 | Binghamton CH | Hard | QF | 192 | 90 | (WC)Nishikori d. (1)Brian Dabul [ARG] | 7-6(5) 6-2 | | 1.53 | 5.0% | 3.3% | 61.7% | 78.4% | 69.6% | 0/0 | 1:36 |
| 9‑Aug‑2010 | Binghamton CH | Hard | R16 | 192 | 269 | (WC)Nishikori d. Benjamin Balleret [MON] | 6-3 6-4 | | 1.48 | 1.7% | 3.4% | 54.2% | 81.3% | 55.6% | 5/6 | 1:20 |
| 9‑Aug‑2010 | Binghamton CH | Hard | R32 | 192 | 148 | (WC)Nishikori d. (5)Kevin Kim [USA] | 7-6(4) 3-6 6-2 | | 1.16 | 4.7% | 5.8% | 60.5% | 73.1% | 47.1% | 3/7 | 2:11 |
| 1‑Aug‑2010 | Washington | Hard | R64 | 196 | 124 | (Q)Igor Kunitsyn [RUS] d. (Q)Nishikori | 6-2 6-3 | | 0.60 | 5.4% | 3.6% | 67.9% | 68.4% | 27.8% | 4/7 | 1:08 |
| 1‑Aug‑2010 | Washington | Hard | Q2 | 196 | 84 | (12)Nishikori d. (1)Kevin Anderson [RSA] | 4-6 7-6(4) 6-4 | | 0.85 | 0.0% | 1.7% | 64.5% | 66.7% | 60.5% | 9/11 | 2:41 |
| 1‑Aug‑2010 | Washington | Hard | Q1 | 196 | 1331 | (12)Nishikori d. (WC)Junior Ore [USA] | 6-3 6-1 | | 1.90 | 6.8% | 2.3% | 61.4% | 85.2% | 47.1% | 2/3 | 0:57 |
| 26‑Jul‑2010 | Los Angeles | Hard | Q2 | 194 | 192 | Tim Smyczek [USA] d. Nishikori | 6-3 6-4 | | 0.88 | 0.0% | 1.9% | 73.6% | 61.5% | 78.6% | 3/5 | 1:15 |
| 26‑Jul‑2010 | Los Angeles | Hard | Q1 | 194 | 210 | Nishikori d. Lester Cook [USA] | 7-6(2) 6-4 | | 1.42 | 0.0% | 4.5% | 57.6% | 76.3% | 57.1% | 1/3 | 1:43 |
| 21‑Jun‑2010 | Wimbledon | Grass | R128 | 189 | 1 | (2)Rafael Nadal [ESP] d. (WC)Nishikori | 6-2 6-4 6-4 | | 0.63 | 3.8% | 7.6% | 62.9% | 71.2% | 33.3% | 8/13 | 2:05 |
| 13‑Jun‑2010 | Eastbourne | Grass | R32 | 204 | 272 | (Q)Andrey Kuznetsov [RUS] d. (Q)Nishikori | 6-4 3-1 RET | | 0.77 | 6.5% | 4.3% | 67.4% | 74.2% | 33.3% | 0/2 | 0:49 |
| 13‑Jun‑2010 | Eastbourne | Grass | Q3 | 204 | 103 | (5)Nishikori d. (3)Igor Kunitsyn [RUS] | 4-6 6-4 6-3 | | 1.24 | 4.4% | 5.6% | 57.8% | 73.1% | 52.6% | 7/11 | 2:04 |
| 13‑Jun‑2010 | Eastbourne | Grass | Q2 | 204 | 1259 | (5)Nishikori d. Nick Cavaday [GBR] | 6-1 6-4 | | 1.42 | 2.0% | 3.9% | 80.4% | 68.3% | 50.0% | 2/3 | 0:55 |
| 13‑Jun‑2010 | Eastbourne | Grass | Q1 | 204 | 1160 | (5)Nishikori d. Haydn Lewis [BAR] | 6-2 6-4 | | 1.47 | 7.3% | 5.5% | 60.0% | 72.7% | 68.2% | 2/2 | 1:09 |
| 7‑Jun‑2010 | Queen's Club | Grass | R64 | 201 | 45 | (11)Richard Gasquet [FRA] d. Nishikori | 6-3 6-3 | | 0.72 | 1.8% | 7.0% | 66.7% | 60.5% | 47.4% | 4/7 | 1:20 |
| 24‑May‑2010 | Roland Garros | Clay | R64 | 246 | 3 | (3)Novak Djokovic [SRB] d. Nishikori | 6-1 6-4 6-4 | | 0.86 | 1.1% | 1.1% | 60.0% | 56.1% | 44.7% | 8/14 | 2:40 |
| 24‑May‑2010 | Roland Garros | Clay | R128 | 246 | 58 | Nishikori d. Santiago Giraldo [COL] | 2-6 4-6 7-6(3) 6-2 6-4 | | 1.16 | 2.8% | 0.7% | 57.4% | 72.8% | 63.3% | 7/10 | 3:36 |
| 10‑May‑2010 | Sarasota CH | Clay | F | 345 | 132 | Nishikori d. (4)Brian Dabul [ARG] | 2-6 6-3 6-4 | | 1.22 | 6.7% | 2.7% | 65.3% | 77.6% | 46.2% | 3/6 | 2:05 |
| 10‑May‑2010 | Sarasota CH | Clay | SF | 345 | 124 | Nishikori d. (6)Ryan Sweeting [USA] | 6-4 6-2 | | 1.92 | 2.1% | 2.1% | 54.2% | 76.9% | 68.2% | 0/1 | 1:03 |
| 10‑May‑2010 | Sarasota CH | Clay | QF | 345 | 409 | Nishikori d. (LL)Bruno Rodriguez [MEX] | 6-1 6-2 | | 1.93 | 6.0% | 2.0% | 64.0% | 75.0% | 66.7% | 2/2 | 1:04 |
| 10‑May‑2010 | Sarasota CH | Clay | R16 | 345 | 202 | Nishikori d. Tim Smyczek [USA] | 6-4 6-3 | | 1.57 | 6.0% | 0.0% | 60.0% | 76.7% | 70.0% | 0/0 | 1:20 |
| 10‑May‑2010 | Sarasota CH | Clay | R32 | 345 | | Nishikori d. (WC)Vamsee Chappidi [IND] | 6-1 6-1 | | 2.87 | 0.0% | 2.6% | 63.2% | 79.2% | 78.6% | 2/2 | 0:50 |
| 3‑May‑2010 | Savannah CH | Clay | F | 649 | 134 | Nishikori d. (4)Ryan Sweeting [USA] | 6-4 6-0 | | 1.67 | 2.1% | 2.1% | 57.4% | 66.7% | 70.0% | 1/2 | 1:20 |
| 3‑May‑2010 | Savannah CH | Clay | SF | 649 | 304 | Nishikori d. Joseph Sirianni [AUS] | 6-1 6-1 | | 2.48 | 4.9% | 2.4% | 70.7% | 75.9% | 66.7% | 0/0 | 0:46 |
| 3‑May‑2010 | Savannah CH | Clay | QF | 649 | 164 | Nishikori d. (8)Robert Kendrick [USA] | 6-2 6-1 | | 1.34 | 2.6% | 0.0% | 61.5% | 58.3% | 40.0% | 6/9 | 1:03 |
| 3‑May‑2010 | Savannah CH | Clay | R16 | 649 | 252 | Nishikori d. James Ward [GBR] | 6-7(0) 6-1 6-4 | | 1.03 | 0.0% | 3.6% | 56.3% | 65.1% | 34.7% | 10/15 | 2:45 |
| 3‑May‑2010 | Savannah CH | Clay | R32 | 649 | 476 | Nishikori d. (Q)Cecil Mamiit [PHI] | 6-4 6-3 | | 1.24 | 1.7% | 1.7% | 62.1% | 66.7% | 50.0% | 4/6 | 1:22 |
| 19‑Apr‑2010 | Tallahassee CH | Hard | QF | 799 | 108 | (4)Robby Ginepri [USA] d. Nishikori | 6-2 6-4 | | 0.83 | 3.7% | 1.9% | 59.3% | 62.5% | 45.5% | 5/8 | 1:18 |
| 19‑Apr‑2010 | Tallahassee CH | Hard | R16 | 799 | 256 | Nishikori d. Tatsuma Ito [JPN] | 4-6 6-4 6-3 | | 1.04 | 2.4% | 4.7% | 54.1% | 73.9% | 53.8% | 1/4 | 1:51 |
| 19‑Apr‑2010 | Tallahassee CH | Hard | R32 | 799 | 109 | Nishikori d. (5)Jesse Levine [CAN] | 6-3 6-7(5) 7-6(3) | | 1.31 | 3.7% | 2.8% | 59.8% | 68.8% | 72.1% | 1/3 | 2:33 |
| 12‑Apr‑2010 | Baton Rouge CH | Hard | QF | | 177 | Tobias Kamke [GER] d. Nishikori | 6-4 6-1 | | 0.62 | 0.0% | 1.9% | 64.2% | 64.7% | 31.6% | 3/7 | 1:13 |
| 12‑Apr‑2010 | Baton Rouge CH | Hard | R16 | | 93 | Nishikori d. (1)Rajeev Ram [USA] | 6-3 6-7(3) 6-3 | | 1.16 | 3.1% | 4.1% | 67.0% | 73.8% | 56.3% | 3/4 | 2:09 |
| 12‑Apr‑2010 | Baton Rouge CH | Hard | R32 | | 215 | Nishikori d. Brendan Evans [USA] | 3-6 6-1 6-1 | | 1.36 | 1.3% | 6.7% | 46.7% | 60.0% | 62.5% | 7/9 | 1:40 |
| 22‑Feb‑2010 | Delray Beach | Hard | R32 | 898 | 40 | (3)Benjamin Becker [GER] d. Nishikori | 6-3 1-6 6-0 | | 0.86 | 1.6% | 7.9% | 50.8% | 62.5% | 54.8% | 4/8 | 1:17 |
