| 19‑Apr‑2021 | Barcelona | Clay | R16 | 3 | 39 | (1)Nadal d. Kei Nishikori [JPN] | 6-0 2-6 6-2 | | 1.20 | 2.4% | 3.7% | 59.8% | 65.3% | 51.5% | 11/13 | 2:19 |
| 27‑May‑2019 | Roland Garros | Clay | QF | 2 | 7 | (2)Nadal d. (7)Kei Nishikori [JPN] | 6-1 6-1 6-3 | | 1.78 | 4.3% | 4.3% | 72.5% | 76.0% | 52.6% | 4/5 | 1:51 |
| 16‑Apr‑2018 | Monte Carlo Masters | Clay | F | 1 | 36 | (1)Nadal d. Kei Nishikori [JPN] | 6-3 6-2 | (ch) | 1.53 | 1.9% | 5.6% | 70.4% | 73.7% | 56.3% | 1/2 | 1:33 |
| 8‑Aug‑2016 | Rio Olympics | Hard | BR | 5 | 7 | (4)Kei Nishikori [JPN] d. (3)Nadal | 6-2 6-7(1) 6-3 | (ch) | 0.75 | 4.7% | 0.9% | 77.4% | 59.8% | 45.8% | 8/13 | 2:49 |
| 18‑Apr‑2016 | Barcelona | Clay | F | 5 | 6 | (1)Nadal d. (2)Kei Nishikori [JPN] | 6-4 7-5 | (ch) | 1.09 | 1.2% | 1.2% | 73.8% | 59.7% | 50.0% | 10/13 | 2:04 |
| 7‑Mar‑2016 | Indian Wells Masters | Hard | QF | 5 | 6 | (4)Nadal d. (5)Kei Nishikori [JPN] | 6-4 6-3 | | 1.20 | 2.9% | 1.4% | 88.6% | 62.9% | 50.0% | 6/8 | 1:33 |
| 10‑Aug‑2015 | Canada Masters | Hard | QF | 9 | 4 | (4)Kei Nishikori [JPN] d. (7)Nadal | 6-2 6-4 | | 0.75 | 7.4% | 11.1% | 55.6% | 66.7% | 37.5% | 0/4 | |
| 4‑May‑2014 | Madrid Masters | Clay | F | 1 | 12 | (1)Nadal d. (10)Kei Nishikori [JPN] | 2-6 6-4 3-0 RET | (ch) | 1.34 | 7.3% | 3.6% | 78.2% | 72.1% | 58.3% | 3/6 | 1:43 |
| 13‑Jan‑2014 | Australian Open | Hard | R16 | 1 | 17 | (1)Nadal d. (16)Kei Nishikori [JPN] | 7-6(3) 7-5 7-6(3) | (ch) | 1.20 | 9.7% | 0.8% | 71.0% | 76.1% | 38.9% | 6/10 | 3:17 |
| 27‑May‑2013 | Roland Garros | Clay | R16 | 4 | 15 | (3)Nadal d. (13)Kei Nishikori [JPN] | 6-4 6-1 6-3 | | 1.57 | 1.3% | 0.0% | 69.2% | 72.2% | 66.7% | 4/4 | 2:02 |
| 21‑Mar‑2012 | Miami Masters | Hard | R16 | 2 | 16 | (2)Nadal d. (16)Kei Nishikori [JPN] | 6-4 6-4 | | 1.30 | 4.6% | 4.6% | 61.5% | 77.5% | 44.0% | 6/8 | 2:10 |
| 23‑Mar‑2011 | Miami Masters | Hard | R64 | 1 | 62 | (1)Nadal d. Kei Nishikori [JPN] | 6-4 6-4 | | 1.34 | 3.2% | 3.2% | 58.7% | 75.7% | 69.2% | 4/4 | 1:49 |
| 21‑Jun‑2010 | Wimbledon | Grass | R128 | 1 | 189 | (2)Nadal d. (WC)Kei Nishikori [JPN] | 6-2 6-4 6-4 | | 1.59 | 10.3% | 3.8% | 69.2% | 81.5% | 54.2% | 2/3 | 2:05 |
| 9‑Jun‑2008 | Queen's Club | Grass | R16 | 2 | 113 | (1)Nadal d. Kei Nishikori [JPN] | 6-4 3-6 6-3 | | 1.06 | 9.7% | 2.2% | 66.7% | 74.2% | 54.8% | 5/6 | 2:04 |
