| 13‑Jan‑2025 | Australian Open | Hard | F | 1 | 2 | (1)Sinner d. (2)Alexander Zverev [GER] | 6-3 7-6(4) 6-3 | (ch) | 1.52 | 6.3% | 2.1% | 60.0% | 84.2% | 63.2% | 0/0 | 2:42 |
| 12‑Aug‑2024 | Cincinnati Masters | Hard | SF | 1 | 4 | (1)Sinner d. (3)Alexander Zverev [GER] | 7-6(9) 5-7 7-6(4) | (ch) | 1.08 | 10.2% | 0.8% | 61.9% | 69.9% | 64.4% | 2/5 | 3:07 |
| 28‑Aug‑2023 | US Open | Hard | R16 | 6 | 12 | (12)Alexander Zverev [GER] d. (6)Sinner | 6-4 3-6 6-2 4-6 6-3 | (ch) | 0.91 | 7.5% | 4.4% | 53.8% | 68.6% | 50.0% | 8/14 | 4:41 |
| 11‑Apr‑2022 | Monte Carlo Masters | Clay | QF | 12 | 3 | (2)Alexander Zverev [GER] d. (9)Sinner | 5-7 6-3 7-6(5) | | 0.91 | 3.0% | 3.0% | 55.0% | 72.7% | 37.8% | 3/8 | 3:07 |
| 30‑Aug‑2021 | US Open | Hard | R16 | 16 | 4 | (4)Alexander Zverev [GER] d. (13)Sinner | 6-4 6-4 7-6(7) | (ch) | 0.89 | 4.7% | 1.9% | 60.4% | 73.4% | 50.0% | 8/11 | 2:25 |
| 19‑Oct‑2020 | Cologne 2 | Hard | SF | 46 | 7 | (1)Alexander Zverev [GER] d. (WC)Sinner | 7-6(3) 6-3 | | 0.89 | 1.6% | 8.2% | 60.7% | 62.2% | 45.8% | 3/7 | 1:48 |
| 28‑Sep‑2020 | Roland Garros | Clay | R16 | 75 | 7 | Sinner d. (6)Alexander Zverev [GER] | 6-3 6-3 4-6 6-3 | (ch) | 1.07 | 2.1% | 4.2% | 56.6% | 71.6% | 53.2% | 6/8 | 3:01 |
