| 13‑Jan‑2025 | Australian Open | Hard | R128 | | 92 | Jacob Fearnley [GBR] d. Kyrgios | 7-6(3) 6-3 7-6(2) | | 0.67 | 10.9% | 6.7% | 73.1% | 69.0% | 43.8% | 9/11 | 2:19 |
| 17‑Jan‑2022 | Australian Open | Hard | R64 | 115 | 2 | (2)Daniil Medvedev [RUS] d. Kyrgios | 7-6(1) 6-4 4-6 6-2 | (ch) | 0.73 | 13.3% | 1.6% | 71.1% | 73.6% | 37.8% | 7/11 | 2:58 |
| 30‑Aug‑2021 | US Open | Hard | R128 | 86 | 21 | (18)Roberto Bautista Agut [ESP] d. Kyrgios | 6-3 6-4 6-0 | (ch) | 0.65 | 18.2% | 3.0% | 51.5% | 58.8% | 50.0% | 1/6 | 1:48 |
| 26‑Aug‑2019 | US Open | Hard | R32 | 30 | 43 | Andrey Rublev [RUS] d. (28)Kyrgios | 7-6(5) 7-6(5) 6-3 | | 0.68 | 28.6% | 3.8% | 64.8% | 86.8% | 40.5% | 3/4 | 1:51 |
| 14‑Jan‑2019 | Australian Open | Hard | R128 | 52 | 17 | (16)Milos Raonic [CAN] d. Kyrgios | 6-4 7-6(5) 6-4 | (ch) | 0.52 | 16.5% | 2.2% | 74.7% | 75.0% | 69.6% | 5/7 | 1:56 |
| 27‑Aug‑2018 | US Open | Hard | R32 | 30 | 2 | (2)Roger Federer [SUI] d. (30)Kyrgios | 6-4 6-1 7-5 | (ch) | 0.68 | 13.8% | 2.1% | 60.6% | 63.2% | 59.5% | 6/10 | 1:44 |
| 2‑Jul‑2018 | Wimbledon | Grass | R32 | 18 | 28 | (24)Kei Nishikori [JPN] d. (15)Kyrgios | 6-1 7-6(3) 6-4 | | 0.65 | 16.0% | 4.9% | 64.2% | 73.1% | 48.3% | 4/8 | 1:37 |
| 15‑Jan‑2018 | Australian Open | Hard | R16 | 17 | 3 | (3)Grigor Dimitrov [BUL] d. (17)Kyrgios | 7-6(3) 7-6(4) 4-6 7-6(4) | (ch) | 1.00 | 23.2% | 4.5% | 65.2% | 79.2% | 50.0% | 7/9 | 3:26 |
| 27‑Jun‑2016 | Wimbledon | Grass | R16 | 18 | 2 | (2)Andy Murray [GBR] d. (15)Kyrgios | 7-5 6-1 6-4 | | 0.49 | 12.6% | 1.1% | 82.8% | 68.1% | 20.0% | 9/13 | 1:42 |
| 23‑May‑2016 | Roland Garros | Clay | R32 | 19 | 12 | (9)Richard Gasquet [FRA] d. (17)Kyrgios | 6-2 7-6(7) 6-2 | | 0.81 | 8.1% | 0.0% | 71.7% | 64.8% | 50.0% | 7/12 | 2:10 |
| 18‑Jan‑2016 | Australian Open | Hard | R32 | 30 | 6 | (6)Tomas Berdych [CZE] d. (29)Kyrgios | 6-3 6-4 1-6 6-4 | | 0.89 | 16.7% | 1.9% | 60.2% | 81.5% | 37.2% | 5/8 | 2:27 |
| 31‑Aug‑2015 | US Open | Hard | R128 | 37 | 3 | (3)Andy Murray [GBR] d. Kyrgios | 7-5 6-3 4-6 6-1 | (ch) | 0.82 | 10.1% | 2.8% | 61.5% | 64.2% | 42.9% | 8/15 | |
| 29‑Jun‑2015 | Wimbledon | Grass | R16 | 29 | 20 | (21)Richard Gasquet [FRA] d. (26)Kyrgios | 7-5 6-1 6-7(7) 7-6(6) | | 0.69 | 14.8% | 6.5% | 61.9% | 72.9% | 42.4% | 9/14 | |
| 24‑May‑2015 | Roland Garros | Clay | R32 | 30 | 3 | (3)Andy Murray [GBR] d. (29)Kyrgios | 6-4 6-2 6-3 | (ch) | 0.74 | 2.0% | 6.9% | 76.5% | 52.6% | 41.7% | 6/13 | 1:59 |
| 19‑Jan‑2015 | Australian Open | Hard | QF | 53 | 6 | (6)Andy Murray [GBR] d. Kyrgios | 6-3 7-6(5) 6-3 | (ch) | 0.60 | 8.2% | 2.7% | 62.7% | 65.2% | 51.2% | 6/9 | 2:05 |
| 19‑Jan‑2015 | Australian Open | Hard | R16 | 53 | 46 | Kyrgios d. Andreas Seppi [ITA] | 5-7 4-6 6-3 7-6(5) 8-6 | (ch) | 1.00 | 13.4% | 3.7% | 62.0% | 75.0% | 52.1% | 9/12 | 3:34 |
| 23‑Jun‑2014 | Wimbledon | Grass | R64 | 144 | 14 | (WC)Kyrgios d. (13)Richard Gasquet [FRA] | 3-6 6-7(4) 6-4 7-5 10-8 | | 0.90 | 10.0% | 2.4% | 67.3% | 70.4% | 56.5% | 14/16 | 3:53 |
| 26‑May‑2014 | Roland Garros | Clay | R128 | 160 | 9 | (8)Milos Raonic [CAN] d. (WC)Kyrgios | 6-3 7-6(1) 6-3 | | 0.78 | 4.3% | 6.5% | 55.9% | 65.4% | 53.7% | 6/10 | 2:00 |
| 31‑Jan‑2014 | Davis Cup WG R1: FRA vs AUS | Clay | RR | 162 | 9 | Richard Gasquet [FRA] d. Kyrgios | 7-6(3) 6-2 6-2 | | | | | | | | | |
| 26‑Aug‑2013 | US Open | Hard | R128 | 212 | 4 | (4)David Ferrer [ESP] d. (Q)Kyrgios | 7-5 6-3 6-2 | | 0.60 | 8.4% | 3.2% | 69.5% | 66.7% | 31.0% | 6/11 | 1:51 |
| 27‑May‑2013 | Roland Garros | Clay | R64 | 262 | 11 | (10)Marin Cilic [CRO] d. (WC)Kyrgios | 6-4 6-2 6-2 | | 0.44 | 3.8% | 5.0% | 63.7% | 64.7% | 34.5% | 2/7 | 1:38 |
